Plasma N terminal pro-brain natriuretic peptide and cardiotrophin 1 are raised in unstable angina

被引:122
作者
Talwar, S [1 ]
Squire, IB [1 ]
Downie, PF [1 ]
Davies, JE [1 ]
Ng, LL [1 ]
机构
[1] Univ Leicester, Leicester Royal Infirm, Dept Med & Therapeut, Leicester LE2 7LX, Leics, England
关键词
cardiotrophin I; brain natriuretic peptide; angina pectoris;
D O I
10.1136/heart.84.4.421
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-To compare circulating concentrations of N terminal pro-brain natriuretic peptide (N-BNP) and cardiotrophin 1 in stable and unstable angina. Design and setting-Observational study in a teaching hospital. Patients-15 patients with unstable angina, 10 patients with stable angina, and 15 controls. Main outcome measures-Resting plasma N-BNP and cardiotrophin 1 concentrations. Results-N-BNP concentration (median (range)) was 714 fmol/ml (177-3217 fmol/ml) in unstable angina, 169.5 fmol/ml (105.7-399.5 fmol/ml) in stable angina (p = 0.005 v unstable angina), and 150.5 fmol/ml (104.7-236.9 fmol/ml) in controls (p < 0.0001 v unstable angina; NS v stable angina). Cardiotrophin 1 concentration was 142.5 fmol/ml (42.2-527.4 fmol/ml) in unstable angina, 73.2 fmol/ml (41.5-102.1 fmol/ml) in stable angina (p < 0.05 v unstable angina), and 27 fmol/ml (6.9-54.1 fmol/ml) in controls (p < 0.0005 v stable angina; p < 0.0001 v unstable angina). Log cardiotrophin I correlated with log N-BNP in unstable angina (r = 0.93, p < 0.0001). Conclusions-Both circulating N-BNP and cardiotrophin 1 are raised in unstable angina, while cardiotrophin I alone is raised in stable angina. The role of cardiotrophin I and the relation between cardiotrophin 1 and N-BNP in myocardial ischaemia remain to be defined.
引用
收藏
页码:421 / 423
页数:3
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