Identification and Specification of the Mouse Skeletal Stem Cell

被引：647

作者：

Chan, Charles K. F. ^{[1
,5
]}

Seo, Eun Young ^{[1
,5
]}

Chen, James Y. ^{[2
,3
]}

Lo, David ^{[1
,5
]}

McArdle, Adrian ^{[1
,5
]}

Sinha, Rahul ^{[2
,3
,5
]}

Tevlin, Ruth ^{[1
,5
]}

Seita, Jun ^{[2
,3
,5
]}

Vincent-Tompkins, Justin ^{[2
,3
]}

Wearda, Taylor ^{[1
,5
]}

Lu, Wan-Jin ^{[2
,3
,5
]}

Senarath-Yapa, Kshemendra ^{[1
]}

Chung, Michael T. ^{[1
]}

Marecic, Owen ^{[1
]}

Tran, Misha ^{[1
]}

Yan, Kelley S. ^{[4
]}

Upton, Rosalynd ^{[2
,3
]}

Walmsley, Graham G. ^{[1
,5
]}

Lee, Andrew S. ^{[2
,3
]}

Sahoo, Debashis ^{[2
,3
,5
,6
]}

Kuo, Calvin J. ^{[4
]}

Weissman, Irving L. ^{[2
,3
,5
]}

Longaker, Michael T. ^{[1
,5
]}

机构：

[1] Stanford Univ, Dept Surg, Palo Alto, CA 94305 USA

[2] Stanford Univ, Dept Pathol, Palo Alto, CA 94305 USA

[3] Stanford Univ, Dept Dev Biol, Palo Alto, CA 94305 USA

[4] Stanford Univ, Stanford Canc Inst, Palo Alto, CA 94305 USA

[5] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Palo Alto, CA 94305 USA

[6] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

来源：

CELL | 2015年 / 160卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

HEMATOPOIETIC NICHE; BONE; CARTILAGE; GROWTH; ANGIOGENESIS; LINEAGE; VEGF; OSTEOARTHRITIS; REGENERATION; OSSIFICATION;

D O I：

10.1016/j.cell.2014.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment. We demonstrate that mSSC niche factors can be potent inducers of osteogenesis, and several specific combinations of recombinant mSSC niche factors can activate mSSC genetic programs in situ, even in nonskeletal tissues, resulting in de novo formation of cartilage or bone and bone marrow stroma. Inducing mSSC formation with soluble factors and subsequently regulating the mSSC niche to specify its differentiation toward bone, cartilage, or stromal cells could represent a paradigm shift in the therapeutic regeneration of skeletal tissues.

引用

页码：285 / 298

页数：14

共 31 条

[1]

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J].

Arai, F ;

Hirao, A ;

Ohmura, M ;

Sato, H ;

Matsuoka, S ;

Takubo, K ;

Ito, K ;

Koh, GY ;

Suda, T .

CELL, 2004, 118 (02) :149-161

[2]

Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation [J].

Bhumiratana, Sarindr ;

Eton, Ryan E. ;

Oungoulian, Sevan R. ;

Wan, Leo Q. ;

Ateshian, Gerard A. ;

Vunjak-Novakovic, Gordana .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (19) :6940-6945

[3]

"Mesenchymal" Stem Cells [J].

Bianco, Paolo .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, 2014, 30 :677-704

[4]

Bone and the hematopoietic niche: a tale of two stem cells [J].

Bianco, Paolo .

BLOOD, 2011, 117 (20) :5281-5288

[5]

Burr DB, 2004, J RHEUMATOL, V31, P77

[6]

Osteoblastic cells regulate the haematopoietic stem cell niche [J].

Calvi, LM ;

Adams, GB ;

Weibrecht, KW ;

Weber, JM ;

Olson, DP ;

Knight, MC ;

Martin, RP ;

Schipani, E ;

Divieti, P ;

Bringhurst, FR ;

Milner, LA ;

Kronenberg, HM ;

Scadden, DT .

NATURE, 2003, 425 (6960) :841-846

[7]

Carlevaro MF, 2000, J CELL SCI, V113, P59

[8]

Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells [J].

Chan, Charles K. F. ;

Lindau, Paul ;

Jiang, Wen ;

Chen, James Y. ;

Zhang, Lillian F. ;

Chen, Ching-Cheng ;

Seita, Jun ;

Sahoo, Debashis ;

Kim, Jae-Beom ;

Lee, Andrew ;

Park, Sujin ;

Nag, Divya ;

Gong, Yongquan ;

Kulkarni, Subhash ;

Luppen, Cynthia A. ;

Theologis, Alexander A. ;

Wan, Derrick C. ;

DeBoer, Anthony ;

Seo, Eun Young ;

Vincent-Tompkins, Justin D. ;

Loh, Kyle ;

Walmsley, Graham G. ;

Kraft, Daniel L. ;

Wu, Joseph C. ;

Longaker, Michael T. ;

Weissman, Irving L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (31) :12643-12648

[9]

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity [J].

Conboy, Michael J. ;

Conboy, Irina M. ;

Rando, Thomas A. .

AGING CELL, 2013, 12 (03) :525-530

[10]

Tie2 identifies a hematopoietic monocytes required for tumor lineage of proangiogenic vessel formation and a mesenchymal population of pericyte progenitors [J].

De Palma, M ;

Venneri, MA ;

Galli, R ;

Sergi, LS ;

Politi, LS ;

Sampaolesi, M ;

Naldini, L .

CANCER CELL, 2005, 8 (03) :211-226

← 1 2 3 4 →