Sensing the outside world: TSLP regulates barrier immunity

被引:416
作者
Ziegler, Steven F. [1 ]
Artis, David [2 ]
机构
[1] Benaroya Res Inst, Program Immunol, Seattle, WA USA
[2] Univ Penn, Dept Pathobiol, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
THYMIC STROMAL LYMPHOPOIETIN; RESPIRATORY SYNCYTIAL VIRUS; DENDRITIC CELLS INDUCE; HUMAN EPITHELIAL-CELLS; IGM(+) B-CELLS; T-CELLS; ATOPIC-DERMATITIS; TH2; RESPONSES; IN-VITRO; EXPRESSION;
D O I
10.1038/ni.1852
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Subsequent studies have shown that TSLP promotes T helper type 2 (T(H)2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. This review will focus on recent findings indicating that in addition to influencing B cell and DC function, TSLP can promote T(H)2 cytokine-associated inflammation by directly promoting the effector functions of CD4(+) T(H)2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.
引用
收藏
页码:289 / 293
页数:5
相关论文
共 70 条
[1]   A role for TSLP in the development of inflammation in an asthma model [J].
Al-Shami, A ;
Spolski, R ;
Kelly, J ;
Keane-Myers, A ;
Leonard, WJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (06) :829-839
[2]   A role for thymic stromal lymphopoietin in CD4+ T cell development [J].
Al-Shami, A ;
Spolski, R ;
Kelly, J ;
Fry, T ;
Schwartzberg, PL ;
Pandey, A ;
Mackall, CL ;
Leonard, WJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (02) :159-168
[3]   Thymic stfomal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells [J].
Allakhverdi, Zoulfia ;
Comeau, Michael R. ;
Jessup, Heidi K. ;
Yoon, Bo-Rin Park ;
Brewer, Avery ;
Chartier, Suzanne ;
Paquette, Nicole ;
Ziegler, Steven F. ;
Sarfati, Marika ;
Delespesse, Guy .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (02) :253-258
[4]   Thymic stromal lymphopoietin as a mediator of crosstalk between bronchial smooth muscles and mast cells [J].
Allakhverdi, Zoulfia ;
Comeau, Michael R. ;
Jessup, Heidi K. ;
Delespesse, Guy .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (04) :958-960
[5]   Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome [J].
Chavanas, S ;
Bodemer, C ;
Rochat, A ;
Hamel-Teillac, D ;
Ali, M ;
Irvine, AD ;
Bonafé, JL ;
Wilkinson, J ;
Taïeb, A ;
Barrandon, Y ;
Harper, JI ;
de Prost, Y ;
Hovnanian, A .
NATURE GENETICS, 2000, 25 (02) :141-142
[6]   Dendritic cells in intestinal immune regulation [J].
Coombes, Janine L. ;
Powrie, Fiona .
NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :435-446
[7]   A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β- and retinoic acid-dependent mechanism [J].
Coombes, Janine L. ;
Siddiqui, Karima R. R. ;
Arancibia-Carcamo, Carolina V. ;
Hall, Jason ;
Sun, Cheng-Ming ;
Belkaid, Yasmine ;
Powrie, Fiona .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1757-1764
[8]   Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity [J].
Demehri, Shadmehr ;
Liu, Zhenyi ;
Lee, Jonghyeob ;
Lin, Meei-Hua ;
Crosby, Seth D. ;
Roberts, Christopher J. ;
Grigsby, Perry W. ;
Miner, Jeffrey H. ;
Farr, Andrew G. ;
Kopan, Raphael .
PLOS BIOLOGY, 2008, 6 (05) :992-1005
[9]   Skin-Derived TSLP Triggers Progression from Epidermal-Barrier Defects to Asthma [J].
Demehri, Shadmehr ;
Morimoto, Mitsuru ;
Holtzman, Michael J. ;
Kopan, Raphael .
PLOS BIOLOGY, 2009, 7 (05)
[10]   Pollen and eosinophilic esophagitis [J].
Fogg, MI ;
Ruchelli, E ;
Spergel, JM .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 112 (04) :796-797