From terminal alkynes directly to branched amines

被引：31

作者：

Castro, IG ^{[1
]}

Tillack, A ^{[1
]}

Hartung, CG ^{[1
]}

Beller, M ^{[1
]}

机构：

[1] Univ Rostock eV, Leibniz Inst Organ Katalyse IfOK, D-18055 Rostock, Germany

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(03)00448-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The one-pot synthesis of several branched secondary aliphatic amines is described. Hydroamination of terminal alkynes with aliphatic primary amines in the presence of Cp2Ti(eta(2)-Me(3)SiCequivalent toCSiMe(3)) gives the corresponding aldimines as intermediates. Reaction of these in situ produced aldimines with organolithium reagents (n-BuLi, PhLi) provides the alpha-branched amines in an easy way in upto 78% overall yield. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3217 / 3221

页数：5

共 38 条

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