Identification of a novel HLA-B46 allele, B*4602, in Japanese

被引：5

作者：

Akesaka, T

Kashiwase, K

Shimamura, M

Ishikawa, Y

Tanaka, H

Fujii, M

Akaza, T

Hando, K

Yuasa, S

Takahashi, T

Juji, T

机构：

[1] Japanese Red Cross Cent Blood Ctr, Dept Res, Shibuya Ku, Tokyo 1500012, Japan

[2] Hoshi Univ, Inst Med Chem, Tokyo 142, Japan

来源：

TISSUE ANTIGENS | 2000年 / 55卷 / 05期

关键词：

B46; specificity; HLA-B*4602; sequence; new allele;

D O I：

10.1034/j.1399-0039.2000.550511.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The B*4602 was identified in a healthy Japanese donor. The B46 variant antigen differed serologically from B46. The nucleotide sequence of B*4602 differed from that of B*4601 by a single base (from A to G) at position 293 in exon 2. The substitution changed the amino acid Asp at position 74 to Gly. The gene frequency of B*4602 in the Japanese population is extremely low, The presumed haplotype of B*4602 was HLA-A2-Cwl-B*4602-DRB1*09. This is the first report of polymorphism of the B46 antigen.

引用

页码：460 / 462

页数：3

共 5 条

[1] Nomenclature for factors of the HLA system, 1998 [J].

Bodmer, JG ;

Marsh, SGE ;

Albert, ED ;

Bodmer, WF ;

Bontrop, RE ;

Dupont, B ;

Erlich, HA ;

Hansen, JA ;

Mach, B ;

Mayr, WR ;

Parham, P ;

Petersdorf, EW ;

Sasazuki, T ;

Schreuder, GMT ;

Strominger, JL ;

Svejgaard, A ;

Terasaki, PI .

TISSUE ANTIGENS, 1999, 53 (04) :407-446

[2] Dimorphic primers derived from intron I for use in the molecular typing of HLA-B alleles [J].

Cereb, N ;

Yang, SY .

TISSUE ANTIGENS, 1997, 50 (01) :74-76

[3] Nucleotide sequences of MHC class I introns 1, 2, and 3 in humans and intron 2 in nonhuman primates [J].

Cereb, N ;

Kong, Y ;

Lee, S ;

Maye, P ;

Yang, SY .

TISSUE ANTIGENS, 1996, 47 (06) :498-511

[4]

Imanishi T., 1992, HLA 1991, P1065

[5] Routine low and high resolution typing of the HLA-DRB gene using the PCR-MPH (microtitre plate hybridization) method [J].

Kawai, S ;

Maekawajiri, S ;

Tokunaga, K ;

Kashiwase, K ;

Miyamoto, M ;

Akaza, T ;

Juji, T ;

Yamane, A .

EUROPEAN JOURNAL OF IMMUNOGENETICS, 1996, 23 (06) :471-486

← 1 →