Studies of the 1996-1997 inactivated influenza vaccine among children attending day care: Immunologic response, protection against infection, anti clinical effectiveness

被引:94
作者
Hurwitz, ES
Haber, M
Chang, A
Shope, T
Teo, ST
Giesick, JS
Ginsberg, MM
Cox, NJ
机构
[1] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA
[2] Emory Univ, Atlanta, GA 30322 USA
[3] San Diego State Univ, San Diego, CA 92182 USA
[4] San Diego Naval Med Ctr, San Diego, CA USA
[5] San Diego Cty Hlth Dept, San Diego, CA USA
关键词
D O I
10.1086/315820
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A randomized, blinded, pilot study of influenza vaccine administered to children attending day care centers was conducted during the 1996-1997 winter. Vaccine efficacy in preventing serologically proven influenza virus infection was 0.45 (95% confidence limit [CL]: - 0.02, 0.69) for influenza B and 0.31 (95% CL: -0.95, 0.73) for influenza A(H3N2), For both influenza A(H3N2) and B, children without preexisting hemagglutination inhibition (HI) antibody to these antigens had lower antibody responses to vaccine, were less likely to develop a serological response, and were more likely to develop serological evidence of influenza infection, Although there were no reductions in respiratory or febrile respiratory illnesses among all vaccinated children, there was a trend for reductions in such illnesses among vaccinated children with preexisting HI antibodies to influenza A(H3N2) and B. Therefore, immunologic priming in young children may be important for vaccine response and for protection against infection, Larger studies are needed in other influenza seasons to assess vaccine efficacy and clinical effectiveness.
引用
收藏
页码:1218 / 1221
页数:4
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