Is birth weight a risk factor for ischemic heart disease in later life?

被引:213
作者
Huxley, Rachel
Owen, Christopher G.
Whincup, Peter H.
Cook, Derek G.
Rich-Edwards, Janet
Smith, George Davey
Collins, Rory
机构
[1] Univ Sydney, George Inst, Royal Prince Alfred Hosp, Sydney, NSW, Australia
[2] Univ London, Div Community Hlth Sci, London WC1E 7HU, England
[3] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA 02115 USA
[4] Harvard Univ, Harvard Pilgrim Hlth Care, Boston, MA 02115 USA
[5] Univ Bristol, Dept Social Med, Bristol BS8 1TH, Avon, England
[6] Univ Oxford, Clin Trial Serv Unit, Oxford OX1 2JD, England
[7] Univ Oxford, Epidemiol Studies Unit, Oxford OX1 2JD, England
关键词
birth weight; ischemic heart disease; follow-up studies;
D O I
10.1093/ajcn/85.5.1244
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: An inverse association between birth weight and ischemic heart disease (IHD) has been seen in observational studies. Objective: We wanted to determine the strength and consistency of the association between birth weight and subsequent IHD. Design: We conducted a systematic review of observational studies. Results: Seventeen published studies of birth weight and subsequent IHD were identified that included a total of 144 794 singletons. Relative risk estimates for the association between birth weight and IHD were available from 16 of these studies. Additional data from 2 unpublished studies of 3801 persons were also included. In total, the analyses included data from 18 studies on 4210 nonfatal and 3308 fatal IHD events in 147 009 persons. The mean weighted estimate for the association between birth weight and the combined outcome of nonfatal and fatal IHD was 0.84 (95% CI: 0.81, 0.88) per kilogram of birth weight (P < 0.0001). No significant heterogeneity was observed between estimates in different studies (P = 0.09), nor was there evidence of publication bias (P = 0.3, Begg test). Neither restricting the analysis to fatal IHD events nor adjusting for socioeconomic status had any appreciable effect on the findings. Conclusions: These findings are consistent with a I kg higher birth weight being associated with a 10-20% lower risk of subsequent IHD. However, even if causal, interventions to increase birth weight are unlikely to reduce the incidence of IHD materially. Further studies are needed to determine whether the observed association reflects a stronger underlying association with a related exposure or is due (at least in part) to residual confounding.
引用
收藏
页码:1244 / 1250
页数:7
相关论文
共 66 条
[1]   Birth dimensions, parental mortality, and mortality in early adult age: a cohort study of Danish men born in 1953 [J].
Andersen, AMN ;
Osler, M .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2004, 33 (01) :92-99
[2]  
[Anonymous], 1998, MOTHERS BABIES DIS L
[3]   Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins [J].
Baigent, C ;
Keech, A ;
Kearney, PM ;
Blackwell, L ;
Buck, G ;
Pollicino, C ;
Kirby, A ;
Sourjina, T ;
Peto, R ;
Collins, R ;
Simes, J .
LANCET, 2005, 366 (9493) :1267-1278
[4]  
BARKER DJP, 1989, LANCET, V2, P577
[5]   THE RELATION OF SMALL HEAD CIRCUMFERENCE AND THINNESS AT BIRTH TO DEATH FROM CARDIOVASCULAR-DISEASE IN ADULT LIFE [J].
BARKER, DJP ;
OSMOND, C ;
SIMMONDS, SJ ;
WIELD, GA .
BRITISH MEDICAL JOURNAL, 1993, 306 (6875) :422-426
[6]   THE INTRAUTERINE ORIGINS OF CARDIOVASCULAR-DISEASE [J].
BARKER, DJP .
ACTA PAEDIATRICA, 1993, 82 :93-99
[7]   OPERATING CHARACTERISTICS OF A BANK CORRELATION TEST FOR PUBLICATION BIAS [J].
BEGG, CB ;
MAZUMDAR, M .
BIOMETRICS, 1994, 50 (04) :1088-1101
[8]   DEPRIVATION IN INFANCY OR IN ADULT LIFE - WHICH IS MORE IMPORTANT FOR MORTALITY RISK [J].
BENSHLOMO, Y ;
SMITH, GD .
LANCET, 1991, 337 (8740) :530-534
[9]   Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease [J].
Beral, V ;
Bull, D ;
Doll, R ;
Peto, R ;
Reeves, G .
LANCET, 2001, 358 (9291) :1389-1399
[10]   Maternal cigarette smoking during pregnancy, low birth weight and subsequent blood pressure in early childhood [J].
Blake, KV ;
Gurrin, LC ;
Evans, SF ;
Beilin, LJ ;
Landau, LI ;
Stanley, FJ ;
Newnham, JP .
EARLY HUMAN DEVELOPMENT, 2000, 57 (02) :137-147