Self-cutting to kill: New insights into the processing of toxins

被引：4

作者：

Aktories, Klaus ^{[1
]}

机构：

[1] Univ Freiburg, Inst Expt & Clin Pharmacol & Toxicol, D-79104 Freiburg, Germany

来源：

ACS CHEMICAL BIOLOGY | 2007年 / 2卷 / 04期

关键词：

D O I：

10.1021/cb7000654

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clostridium difficile toxins A and B are the major cause of antibiotic-associated diarrhea and pseudomembranous colitis. The toxins are one of the biggest protein toxins known, but only the N-terminal catalytic domains of the large proteins enter the cytosol. Now, a new study shows that the toxins are processed by autocatalytic cleavage, which depends on the presence of inositol hexaphosphate.

引用

页码：228 / 230

页数：3

共 20 条

[1] Bacterial cytotoxins: Targeting eukaryotic switches [J].

Aktories, K ;

Barbieri, JT .

NATURE REVIEWS MICROBIOLOGY, 2005, 3 (05) :397-410

[2] Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells [J].

Barth, H ;

Pfeifer, G ;

Hofmann, F ;

Maier, E ;

Benz, R ;

Aktories, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (14) :10670-10676

[3] CLINDAMYCIN-ASSOCIATED COLITIS DUE TO A TOXIN-PRODUCING SPECIES OF CLOSTRIDIUM IN HAMSTERS [J].

BARTLETT, JG ;

ONDERDONK, AB ;

CISNEROS, RL ;

KASPER, DL .

JOURNAL OF INFECTIOUS DISEASES, 1977, 136 (05) :701-705

[4] Rho and Rac take center stage [J].

Burridge, K ;

Wennerberg, K .

CELL, 2004, 116 (02) :167-179

[5] Interactions between HIV-1 Gag molecules in solution: An inositol phosphate-mediated switch [J].

Datta, Siddhartha A. K. ;

Zhao, Zhuojun ;

Clark, Patrick K. ;

Tarasov, Sergey ;

Alexandratos, Jerry N. ;

Campbell, Stephen J. ;

Kvaratskhelia, Mamuka ;

Lebowitz, Jacob ;

Rein, Alan .

JOURNAL OF MOLECULAR BIOLOGY, 2007, 365 (03) :799-811

[6] Carbohydrate recognition by Clostridium difficile toxin A [J].

Greco, A ;

Ho, JGS ;

Lin, SJ ;

Palcic, MM ;

Rupnik, M ;

Ng, KKS .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (05) :460-461

[7] Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A [J].

Ho, JGS ;

Greco, A ;

Rupnik, M ;

Ng, KKS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (51) :18373-18378

[8] Rho GTPases: Biochemistry and biology [J].

Jaffe, AB ;

Hall, A .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2005, 21 :247-269

[9] Large clostridial cytotoxins [J].

Just, I ;

Gerhard, R .

REVIEWS OF PHYSIOLOGY, BIOCHEMICAL AND PHARMACOLOGY, VOL 152, 2005, 152 :23-47

[10] GLUCOSYLATION OF RHO-PROTEINS BY CLOSTRIDIUM-DIFFICILE TOXIN-B [J].

JUST, I ;

SELZER, J ;

WILM, M ;

VONEICHELSTREIBER, C ;

MANN, M ;

AKTORIES, K .

NATURE, 1995, 375 (6531) :500-503

← 1 2 →