Targeted hyperthermia using metal nanoparticles

被引：419

作者：

Cherukuri, Paul ^{[1
,2
,3
,4
]}

Glazer, Evan S. ^{[1
]}

Curleya, Steven A. ^{[1
,5
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[3] Rice Univ, Dept Chem, Houston, TX USA

[4] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MD USA

[5] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 03期

关键词：

Radiofrequency; Thermal therapy; Inorganic nanoparticles; TUMOR-NECROSIS-FACTOR; ISOLATED LIMB PERFUSION; RADIOFREQUENCY ABLATION; GOLD NANOPARTICLES; CARBON NANOTUBES; DRUG-DELIVERY; BREAST-CANCER; QUANTUM DOTS; FACTOR-ALPHA; TRANSPORTERS;

D O I：

10.1016/j.addr.2009.11.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite the use of hyperthermia, to treat cancer for thousands of years, the challenge of only heating malignant cells remains daunting. In pre-clinical and early clinical trials, metal nanoparticles induce hyperthermic cytotoxicity when exposed to near-infrared radiation or radiofrequency fields. We discuss the emerging roles of nanoparticles, especially gold, in the hyperthermic treatment of cancer. In addition, we discuss the similarities of radiofrequency, ablation and nanoparticle mediated cytotoxicity. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：339 / 345

页数：7

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