Simultaneous indocyanine green and fluorescein angiography using a confocal scanning laser ophthalmoscope

被引:70
作者
Freeman, WR [1 ]
Bartsch, DU [1 ]
Mueller, AJ [1 ]
Banker, AS [1 ]
Weinreb, RN [1 ]
机构
[1] Univ Calif San Diego, Shiley Eye Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
关键词
D O I
10.1001/archopht.116.4.455
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Background: Fluorescein and indocyanine green (ICG) angiography are both useful in the diagnosis and treatment of many retinal diseases. In some cases, both tests must be performed for diagnosis and treatment; however, performing both is time-consuming and may require multiple injections. Methods: We designed a compact digital confocal scanning laser ophthalmoscope to perform true simultaneous fluorescein and ICG angiography. We report our experience using the instrument to perform 169 angiograms in 117 patients. Results: There were no unexpected adverse effects from mixing the dyes and administering them in 1 injection. An entire examination, including fundus photography, fluorescein angiography, and ICG angiography, could be performed in 45 minutes. It was possible to study differences in fluorescein patterns by comparing identically timed frames and to find cases in which ICG or fluorescein was optimal in visualizing retinal and subretinal structures. Confocal optical sections in the depth (z) dimension allowed viewing in different planes. It was possible to overlay ICG and fluorescein images or compare them side-by-side using a linked cursor. Digital transmission of the images was also performed. Conclusions: Simultaneous ICG and fluorescein angiography can be performed rapidly, safely, and conveniently. The availability of simultaneous angiography will allow critical determination of the relative advantages and disadvantages of both types of angiography.
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页码:455 / 463
页数:9
相关论文
共 25 条
[1]  
AVVAD FK, 1995, OPHTHALMOLOGY, V102, P401
[2]   CONFOCAL SCANNING INFRARED-LASER OPHTHALMOSCOPY FOR INDOCYANINE GREEN ANGIOGRAPHY [J].
BARTSCH, DU ;
WEINREB, RN ;
ZINSER, G ;
FREEMAN, WR .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1995, 120 (05) :642-651
[3]   CONFOCAL LASER TOMOGRAPHIC ANALYSIS OF THE RETINA IN EYES WITH MACULAR HOLE FORMATION AND OTHER FOCAL MACULAR DISEASES [J].
BARTSCH, DU ;
INTAGLIETTA, M ;
BILLE, JF ;
DREHER, AW ;
GHARIB, M ;
FREEMAN, WR .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1989, 108 (03) :277-287
[4]   AXIAL INTENSITY DISTRIBUTION ANALYSIS OF THE HUMAN RETINA WITH A CONFOCAL SCANNING LASER TOMOGRAPH [J].
BARTSCH, DU ;
FREEMAN, WR .
EXPERIMENTAL EYE RESEARCH, 1994, 58 (02) :161-173
[5]  
BARTSCH DU, 1993, NEUROSCI BIOBEHAV R, V17, P459
[6]  
BISCHOFF PM, 1995, RETINA-J RET VIT DIS, V15, P91, DOI 10.1097/00006982-199515020-00002
[7]   10 YEARS EXPERIENCE WITH CHOROIDAL ANGIOGRAPHY USING INDOCYANINE GREEN-DYE - A NEW ROUTINE EXAMINATION OR AN EPILOGUE [J].
BISCHOFF, PM ;
FLOWER, RW .
DOCUMENTA OPHTHALMOLOGICA, 1985, 60 (03) :235-291
[8]   LANDMARK INJECTION FOR LOCALIZATION OF CHOROIDAL LESIONS USING INDOCYANINE GREEN ANGIOGRAPHY [J].
BRUCKER, AJ ;
BRANT, A ;
NYBERG, W .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 1993, 13 (02) :169-171
[9]  
CLARK TM, 1992, RETINA, V76, P68
[10]  
FLOWER RW, 1973, INVEST OPHTH VISUAL, V12, P248