The yin and yang of NMDA receptor signalling

被引：518

作者：

Hardingham, GE

Bading, H

机构：

[1] Univ Edinburgh, Royal Sch Vet Studies, Dept Precin Vet Sci, Edinburgh EH9 1QH, Midlothian, Scotland

[2] Interdisciplinary Ctr Neurosci IZN, Dept Neurobiol, D-69120 Heidelberg, Germany

来源：

TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 02期

关键词：

D O I：

10.1016/S0166-2236(02)00040-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ca2+ entry through the NMDA subtype of glutamate receptors has the power to determine whether neurons survive or die. Too much NMDA receptor activity is harmful to neurons - but so is too little. Is it a case of too much or too little Ca2+ influx causing cell death or do other factors, such as receptor location or receptor-associated proteins, play a role? Understanding the mechanisms behind this dichotomous signalling is an important area of molecular neuroscience with direct clinical implications.

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页码：81 / 89

页数：9

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