Tailoring synthetic polymeric biomaterials towards nerve tissue engineering: a review

被引：92

作者：

Amani, Hamed ^{[1
]}

Kazerooni, Hanif ^{[2
]}

Hassanpoor, Hossein ^{[3
]}

Akbarzadeh, Abolfazl ^{[4
]}

Pazoki-Toroudi, Hamidreza ^{[5
,6
]}

机构：

[1] Iran Univ Med Sci, Fac Adv Technol Med, Dept Med Nanotechnol, Tehran, Iran

[2] Amirkabir Univ Technol, Tehran Polytech, Dept Chem Engn, Biotechnol Grp, Tehran, Iran

[3] Atynegar DSA Inst, Dept Cognit Sci, Dade Pardazi, Tehran, Iran

[4] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran

[5] Iran Univ Med Sci, Fac Med, Physiol Res Ctr, Tehran, Iran

[6] Iran Univ Med Sci, Fac Med, Dept Physiol, Tehran, Iran

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2019年 / 47卷 / 01期

关键词：

Synthetic polymeric biomaterials; physiochemical properties; nerve tissue engineering; PREVENTS REINNERVATION ACCURACY; PLLA NANOFIBROUS SCAFFOLDS; GUIDANCE CONDUIT; NANOENGINEERED BIOMATERIALS; POLY(PROPYLENE FUMARATE); ALIGNED NANOFIBERS; FIBROUS SCAFFOLDS; POLYVINYL-ALCOHOL; DRUG-DELIVERY; SCHWANN-CELLS;

D O I：

10.1080/21691401.2019.1639723

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The nervous system is known as a crucial part of the body and derangement in this system can cause potentially lethal consequences or serious side effects. Unfortunately, the nervous system is unable to rehabilitate damaged regions following seriously debilitating disorders such as stroke, spinal cord injury and brain trauma which, in turn, lead to the reduction of quality of life for the patient. Major challenges in restoring the damaged nervous system are low regenerative capacity and the complexity of physiology system. Synthetic polymeric biomaterials with outstanding properties such as excellent biocompatibility and non-immunogenicity find a wide range of applications in biomedical fields especially neural implants and nerve tissue engineering scaffolds. Despite these advancements, tailoring polymeric biomaterials for design of a desired scaffold is fundamental issue that needs tremendous attention to promote the therapeutic benefits and minimize adverse effects. This review aims to (i) describe the nervous system and related injuries. Then, (ii) nerve tissue engineering strategies are discussed and (iii) physiochemical properties of synthetic polymeric biomaterials systematically highlighted. Moreover, tailoring synthetic polymeric biomaterials for nerve tissue engineering is reviewed.

引用

页码：3524 / 3539

页数：16

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