Maize Tumors Caused by Ustilago maydis Require Organ-Specific Genes in Host and Pathogen

被引：158

作者：

Skibbe, David S. ^{[1
]}

Doehlemann, Gunther ^{[2
]}

Fernandes, John ^{[1
]}

Walbot, Virginia ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[2] Max Planck Inst Terr Microbiol, D-35043 Marburg, Germany

来源：

SCIENCE | 2010年 / 328卷 / 5974期

关键词：

TRANSCRIPTOME; EFFECTORS; GENOME;

D O I：

10.1126/science.1185775

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infection of maize by corn smut (Ustilago maydis) provides an agronomically important model of biotrophic host-pathogen interactions. After penetration of the maize epidermis, fungal colonization of host tissue induces tumor formation on all aerial maize organs. We hypothesized that transformation of different primordia into plant tumors would require organ-specific gene expression by both host and pathogen and documented these differences by transcriptome profiling. Phenotypic screening of U. maydis mutants deleted for genes encoding secreted proteins and maize mutants with organ-specific defects confirmed organ-restricted tumorigenesis. This is the foundation for exploring how individual pathogen effectors, deployed in an organ-specific pattern, interact with host factors to reprogram normal ontogeny into a tumor pathway.

引用

收藏

页码：89 / 92

页数：4

相关论文

共 19 条

[1]

Banuett F, 2002, MYCOLOGY S, V15, P349

[2] Hormonal control of grass inflorescence development [J].

Barazesh, Solmaz ;

McSteen, Paula .

TRENDS IN PLANT SCIENCE, 2008, 13 (12) :656-662

[3] The Maize Transcription Factor KNOTTED1 Directly Regulates the Gibberellin Catabolism Gene ga2ox1 [J].

Bolduc, Nathalie ;

Hake, Sarah .

PLANT CELL, 2009, 21 (06) :1647-1658

[4] Innate Immunity in Plants: An Arms Race Between Pattern Recognition Receptors in Plants and Effectors in Microbial Pathogens [J].

Boller, Thomas ;

He, Sheng Yang .

SCIENCE, 2009, 324 (5928) :742-744

[5] ENDOPOLYPLOIDY IN MAIZE SMUT NEOPLASMS INDUCED BY MAIZE SMUT FUNGUS, USTILAGO-MAYDIS [J].

CALLOW, JA .

NEW PHYTOLOGIST, 1975, 75 (02) :253-&

[6] Effectors of biotrophic fungi and oomycetes: pathogenicity factors and triggers of host resistance [J].

Dodds, Peter N. ;

Rafiqi, Maryam ;

Gan, Pamela H. P. ;

Hardham, Adrienne R. ;

Jones, David A. ;

Ellis, Jeffrey G. .

NEW PHYTOLOGIST, 2009, 183 (04) :993-999

[7] Reprogramming a maize plant: transcriptional and metabolic changes induced by the fungal biotroph Ustilago maydis [J].

Doehlemann, Gunther ;

Wahl, Ramon ;

Horst, Robin J. ;

Voll, Lars M. ;

Usadel, Bjoern ;

Poree, Fabien ;

Stitt, Mark ;

Pons-Kuehnemann, Joern ;

Sonnewald, Uwe ;

Kahmann, Regine ;

Kaemper, Joerg .

PLANT JOURNAL, 2008, 56 (02) :181-195

[8] Pep1, a Secreted Effector Protein of Ustilago maydis, Is Required for Successful Invasion of Plant Cells [J].

Doehlemann, Gunther ;

van der Linde, Karina ;

Amann, Daniela ;

Schwammbach, Daniela ;

Hof, Alexander ;

Mohanty, Amitabh ;

Jackson, David ;

Kahmann, Regine .

PLOS PATHOGENS, 2009, 5 (02)

[9] Distinctive transcriptome responses to adverse environmental conditions in Zea mays L. [J].

Fernandes, John ;

Morrow, Darren J. ;

Casati, Paula ;

Walbot, Virginia .

PLANT BIOTECHNOLOGY JOURNAL, 2008, 6 (08) :782-798

[10] Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis [J].

Kaemper, Joerg ;

Kahmann, Regine ;

Boelker, Michael ;

Ma, Li-Jun ;

Brefort, Thomas ;

Saville, Barry J. ;

Banuett, Flora ;

Kronstad, James W. ;

Gold, Scott E. ;

Mueller, Olaf ;

Perlin, Michael H. ;

Woesten, Han A. B. ;

de Vries, Ronald ;

Ruiz-Herrera, Jose ;

Reynaga-Pena, Cristina G. ;

Snetselaar, Karen ;

McCann, Michael ;

Perez-Martin, Jose ;

Feldbruegge, Michael ;

Basse, Christoph W. ;

Steinberg, Gero ;

Ibeas, Jose I. ;

Holloman, William ;

Guzman, Plinio ;

Farman, Mark ;

Stajich, Jason E. ;

Sentandreu, Rafael ;

Gonzalez-Prieto, Juan M. ;

Kennell, John C. ;

Molina, Lazaro ;

Schirawski, Jan ;

Mendoza-Mendoza, Artemio ;

Greilinger, Doris ;

Muench, Karin ;

Roessel, Nicole ;

Scherer, Mario ;

Vranes, Miroslav ;

Ladendorf, Oliver ;

Vincon, Volker ;

Fuchs, Uta ;

Sandrock, Bjoern ;

Meng, Shaowu ;

Ho, Eric C. H. ;

Cahill, Matt J. ;

Boyce, Kylie J. ;

Klose, Jana ;

Klosterman, Steven J. ;

Deelstra, Heine J. ;

Ortiz-Castellanos, Lucila ;

Li, Weixi .

NATURE, 2006, 444 (7115) :97-101