Genetic chaos and antichaos in human cancers

被引：29

作者：

Calin, GA

Vasilescu, C

Negrini, M

Barbanti-Brodano, G

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Fundeni Clin Hosp, Bucharest, Romania

[3] Univ Ferrara, I-44100 Ferrara, Italy

来源：

MEDICAL HYPOTHESES | 2003年 / 60卷 / 02期

关键词：

D O I：

10.1016/S0306-9877(02)00383-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cancer is considered the genetic disease with the most complex pathogenetic mechanism. Contrary to normal human tissues, which function in a highly ordered and uniform manner, tumor tissues were considered to develop chaos. Here we propose that analysis of human neoplasia according to the concepts of chaos and antichaos allowed to distinguish two main types of cancers: the hematopoietic cancers, characterized by the orderly antichaos and solid cancers governed by a disordered complex of genetic and molecular events characteristic of a chaotic pattern. Genetic chaos and antichaos have generated rules that can be applied to the diagnosis and therapy of human tumors. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：258 / 262

页数：5

共 39 条

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