Developments in clinical cell therapy

被引：43

作者：

Stroncek, David ^{[1
]}

Berlyne, Deborah ^{[2
]}

Fox, Bernard ^{[3
]}

Gee, Adrian ^{[4
]}

Heimfeld, Shelly ^{[5
]}

Lindblad, Robert ^{[2
]}

Loper, Kathy ^{[6
]}

Mckenna, David, Jr. ^{[7
]}

Rooney, Cliona ^{[4
]}

Sabatino, Marianna ^{[1
]}

Wagner, Elizabeth ^{[8
]}

Whiteside, Theresa ^{[9
]}

Wood, Deborah ^{[2
]}

Heath-Mondoro, Traci ^{[8
]}

机构：

[1] NIH, Bethesda, MD 20892 USA

[2] EMMES Corp, Rockville, MD USA

[3] Earle A Chiles Res Inst, Portland, OR USA

[4] Baylor Coll Med, Houston, TX 77030 USA

[5] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[6] AABB, Bethesda, MD USA

[7] Univ Minnesota, St Paul, MN 55108 USA

[8] NHLBI, Div Blood Dis & Resources, Bethesda, MD 20892 USA

[9] Univ Pittsburgh, Pittsburgh, PA USA

来源：

CYTOTHERAPY | 2010年 / 12卷 / 03期

基金：

美国国家卫生研究院;

关键词：

cancer; cell therapy; hematopoietic stem cell transplantation; regenerative medicine; ANTIGEN-PRESENTING CELLS; MESENCHYMAL STEM-CELLS; T-CELLS; IMMUNOTHERAPY; ENGRAFTMENT; PHASE;

D O I：

10.3109/14653240903511952

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Immunotherapy has become an important part of hematopoietic stem cell (HSC) transplantation and cancer therapy. Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, preventing and reversing damage to organs, and restoring balance to compromised immune systems. The principles and practices of the diverse aspects of immune therapy for cancer, HSC transplantation and regenerative medicine have many commonalities. This meeting report summarizes a workshop sponsored by the National Heart, Lung and Blood Institute (NHLBI) and Production Assistance for Cellular Therapies (PACT), held on 23-24 April 2009 at the National Institutes of Health (NIH, USA). A series of scientific sessions and speakers highlighted key aspects of the latest scientific, clinical and technologic developments in cell therapy, involving a unique set of cell products with a special emphasis on converging concepts in these fields.

引用

收藏

页码：425 / 428

页数：4

相关论文

共 16 条

[1]

In vivo imaging platform for tracking immunotherapeutic cells [J].

Ahrens, ET ;

Flores, R ;

Xu, HY ;

Morel, PA .

NATURE BIOTECHNOLOGY, 2005, 23 (08) :983-987

[2]

Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells [J].

Berg, Maria ;

Lundqvist, Andreas ;

McCoy, Philip, Jr. ;

Samsel, Leigh ;

Fan, Yong ;

Tawab, Abdul ;

Childs, Richard .

CYTOTHERAPY, 2009, 11 (03) :341-355

[3]

Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer [J].

Bollard, Catherine M. ;

Gottschalk, Stephen ;

Leen, Ann M. ;

Weiss, Heidi ;

Straathof, Karin C. ;

Carrum, George ;

Khalil, Mariam ;

Wu, Meng-fen ;

Huls, M. Helen ;

Chang, Chung-Che ;

Gresik, M. Victoria ;

Gee, Adrian P. ;

Brenner, Malcolm K. ;

Rooney, Cliona M. ;

Heslop, Helen E. .

BLOOD, 2007, 110 (08) :2838-2845

[4]

Successful Haploidentical Hematopoietic Cell Engraftment Using a Non-Myeloablative Preparative Regimen Including Natural Killer (NK) Cells [J].

Cooley, Sarah ;

Gada, Purvi ;

McKenna, David ;

McCullar, Valarie ;

Fautsch, Susan ;

Verneris, Michael ;

Blazar, Bruce R. ;

Burns, Linda J. ;

McGlave, Philip B. ;

Weisdorf, Daniel J. ;

Miller, Jeffrey S. .

BLOOD, 2008, 112 (11) :307-307

[5]

Preparing clinical grade Ag-specific T cells for adoptive immunotherapy trials [J].

DiGiusto, Dl ;

Cooper, Ljn .

CYTOTHERAPY, 2007, 9 (07) :613-629

[6]

Intracellular phospho-protein staining techniques for flow cytometry: Monitoring single cell signaling events [J].

Krutzik, PO ;

Nolan, GP .

CYTOMETRY PART A, 2003, 55A (02) :61-70

[7]

Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells [J].

Le Blanc, K. ;

Samuelsson, H. ;

Gustafsson, B. ;

Remberger, M. ;

Sundberg, B. ;

Arvidson, J. ;

Ljungman, P. ;

Lonnies, H. ;

Nava, S. ;

Ringden, O. .

LEUKEMIA, 2007, 21 (08) :1733-1738

[8]

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease:: a phase II study [J].

LeBlanc, Katarina ;

Frassoni, Francesco ;

Ball, Lynne ;

Locatelli, Franco ;

Roelofs, Helene ;

Lewis, Ian ;

Lanino, Edoardo ;

Sundberg, Berit ;

Bernardo, Maria Ester ;

Remberger, Mats ;

Dini, Giorgio ;

Egeler, R. Maarten ;

Bacigalupo, Andrea ;

Fibbe, Willem ;

Ringden, Olle .

LANCET, 2008, 371 (9624) :1579-1586

[9]

Gene transfer in humans using a conditionally replicating lentiviral vector [J].

Levine, Bruce L. ;

Humeau, Laurent M. ;

Boyer, Jean ;

MacGregor, Rob-Roy ;

Rebello, Tessio ;

Lu, Xiaobin ;

Binder, Gwendolyn K. ;

Slepushkin, Vladimir ;

Lemiale, Franck ;

Mascola, John R. ;

Bushman, Frederic D. ;

Dropulic, Boro ;

June, Carl H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (46) :17372-17377

[10]

Imaging of mesenchymal stem cell transplant by bioluminescence and PET [J].

Love, Zachary ;

Wang, Fargjing ;

Dennis, James ;

Awadallah, Amad ;

Salem, Nicolas ;

Lin, Yuan ;

Weisenberger, Andrew ;

Majewski, Stan ;

Gerson, Stanton ;

Lee, Zhenghong .

JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (12) :2011-2020