Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination

被引：167

作者：

Jablonska, Beata ^{[1
]}

Aguirre, Adan ^{[1
]}

Raymond, Matthew ^{[1
,2
]}

Szabo, Gabor ^{[3
]}

Kitabatake, Yasuji ^{[4
]}

Sailor, Kurt A. ^{[4
]}

Ming, Guo-Li ^{[4
]}

Song, Hongjun ^{[4
]}

Gallo, Vittorio ^{[1
]}

机构：

[1] Childrens Natl Med Ctr, Ctr Neurosci Res, Washington, DC 20010 USA

[2] George Washington Univ, Inst Biomed Sci, Washington, DC USA

[3] Hungarian Acad Sci, Inst Expt Med, Dept Gene Technol & Dev Neurobiol, Budapest, Hungary

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 05期

基金：

美国国家卫生研究院;

关键词：

BONE MORPHOGENETIC PROTEIN; NEURAL STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; OLIG GENE-FUNCTION; SUBVENTRICULAR ZONE; PROGENITOR CELLS; MULTIPLE-SCLEROSIS; SPINAL-CORD; BRAIN; MOUSE;

D O I：

10.1038/nn.2536

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mechanisms that regulate the developmental potential of adult neural progenitor populations under physiological and pathological conditions remain poorly defined. Glutamic acid decarboxylase 65 (GAD65)- and Doublecortin (Dcx)-expressing cells constitute major progenitor populations in the adult mouse subventricular zone (SVZ). Under normal physiological conditions, SVZ-derived GAD65-positive and Dcx-positive cells expressed the transcription factor Pax6 and migrated along the rostral migratory stream to the olfactory bulb to generate interneurons. After lysolecithin-induced demyelination of corpus callosum, however, these cells altered their molecular and cellular properties and migratory path. Demyelination upregulated chordin in the SVZ, which redirected GAD65-positive and Dcx-positive progenitors from neuronal to glial fates, generating new oligodendrocytes in the corpus callosum. Our findings suggest that the lineage plasticity of SVZ progenitor cells could be a potential therapeutic strategy for diseased or injured brain.

引用

页码：541 / U43

页数：12

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