Early diagnosis of Alzheimer's disease: clinical and economic benefits

被引:196
作者
Leifer, BP
机构
[1] Valley Hosp, Dept Med, Ridgewood, NJ USA
[2] Mt Sinai Sch Med, Dept Geriatr & Adult Dev, New York, NY USA
关键词
Alzheimer's disease; dementia tests; Alzheimer's disease early diagnosis; differential diagosis of Alzheimer's disease;
D O I
10.1046/j.1532-5415.5153.x
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
An estimated four million individuals in the United States have Alzheimer's disease (AD). This number is expected to more than triple by mid-century. Primary care physicians have a key role in evaluating older patients for early signs of dementia and in initiating treatment that can significantly retard its progression over the maximum period of time. That role and its challenges will inevitably grow along with the expected increase in the population aged 65 and older. The tendency for physicians to dismiss memory complaints as normal aging must be replaced by awareness of the need to assess and possibly intervene. Early intervention is the optimal strategy, not only because the patient's level of function will be preserved for a longer period, but also because community-dwelling patients with AD incur less societal cost than those-who require long-term institutional placement. Institutionalization contributes heavily to the annual cost of care for AD in the United States, which is estimated to be $100 billion annually.
引用
收藏
页码:S281 / S288
页数:8
相关论文
共 64 条
  • [1] Aguero-Torres H, 1998, INT J GERIATR PSYCH, V13, P755, DOI 10.1002/(SICI)1099-1166(1998110)13:11<755::AID-GPS862>3.0.CO
  • [2] 2-Y
  • [3] ALEXOPOULOS GS, 1993, AM J PSYCHIAT, V150, P1693
  • [4] Almkvist O, 1998, J NEURAL TRANSM-SUPP, P21
  • [5] [Anonymous], 2000, DIAGN STAT MAN MENT
  • [6] Anxiety, depression and psychosis in vascular dementia: prevalence and associations
    Ballard, C
    Neill, D
    O'Brien, J
    McKeith, IG
    Ince, P
    Perry, R
    [J]. JOURNAL OF AFFECTIVE DISORDERS, 2000, 59 (02) : 97 - 106
  • [7] Postmenopausal hormone replacement therapy for primary prevention of chronic conditions: Recommendations and rationale
    Berg, AO
    Allan, JD
    Frame, P
    Homer, CJ
    Johnson, MS
    Klein, JD
    Lieu, TA
    Orleans, CT
    Peipert, JF
    Pender, NJ
    Siu, AL
    Teutsch, SM
    Woolf, SH
    [J]. ANNALS OF INTERNAL MEDICINE, 2002, 137 (10) : 834 - 839
  • [8] Pharmacologic treatments of dementia
    Bonner, LT
    Peskind, ER
    [J]. MEDICAL CLINICS OF NORTH AMERICA, 2002, 86 (03) : 657 - +
  • [9] Braak H, 1998, J NEURAL TRANSM-SUPP, P127
  • [10] TIME UNTIL INSTITUTIONALIZATION AND DEATH IN PATIENTS WITH DEMENTIA - ROLE OF CAREGIVER TRAINING AND RISK-FACTORS
    BRODATY, H
    MCGILCHRIST, C
    HARRIS, L
    PETERS, KE
    [J]. ARCHIVES OF NEUROLOGY, 1993, 50 (06) : 643 - 650