Expression of GABAA receptor α5 subunit-like immunoreactivity in human hippocampus

被引：24

作者：

Wainwright, A ^{[1
]}

Sirinathsinghji, DS ^{[1
]}

Oliver, KR ^{[1
]}

机构：

[1] Merck Sharp & Dohme Res Labs, Ctr Res Neurosci, Harlow CM20 2QR, Essex, England

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 80卷 / 02期

关键词：

hippocampal formation; human brain; immunohistochemistry; GABA(A);

D O I：

10.1016/S0169-328X(00)00133-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the distribution of GABA(A) receptor alpha 5 subunit expression in brain, polyclonal antisera were raised, characterised and applied to human and rat brain sections. The resultant antibodies detected a major band of 53 kDa in sodium dodecyl sulphate-polyacrylamide gel electrophoresis immunoblots. Abundant immunostaining was demonstrated in the hippocampal formation in multiple cell types, although predominantly in pyramidal neurons. These data are supportive of GABA-ergic involvement in cognition, and suggest that this influence may be mediated through receptors containing the alpha 5 subunit. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：228 / 232

页数：5

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