Central amygdala ERK signaling pathway is critical to incubation of cocaine craving

被引：337

作者：

Lu, L ^{[1
]}

Hope, BT ^{[1
]}

Dempsey, J ^{[1
]}

Liu, SY ^{[1
]}

Bossert, JM ^{[1
]}

Shaham, Y ^{[1
]}

机构：

[1] NIDA, NIH, Dept HHS, Intramural Res Program,Behav Neurosci Branch, Baltimore, MD 21224 USA

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 02期

关键词：

D O I：

10.1038/nn1383

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using a rat model of craving and relapse, we have previously found time-dependent increases in cue-induced cocaine seeking over the first months of withdrawal from cocaine, suggesting that drug craving incubates over time. Here, we explored the role of the amygdala extracellular signal-regulated kinase (ERK) signaling pathway in this incubation. Cocaine seeking induced by exposure to cocaine cues was substantially higher after 30 withdrawal days than after 1 withdrawal day. Exposure to these cues increased ERK phosphorylation in the central, but not the basolateral, amygdala after 30 d, but not 1 d, of withdrawal. After 30 d of withdrawal from cocaine, inhibition of central, but not basolateral, amygdala ERK phosphorylation decreased cocaine seeking. After 1 d of withdrawal, stimulation of central amygdala ERK phosphorylation increased cocaine seeking. Results suggest that the incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway to cocaine cues.

引用

页码：212 / 219

页数：8

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