CuII Cross-Linked Antiparallel Dipeptide Duplexes Using Heterofunctional Ligand-Substituted Aminoethylglycine

被引：7

作者：

Coppock, Matthew B. ^{[1
]}

Kapelewski, Matthew T. ^{[1
]}

Youm, Hye Won ^{[1
]}

Levine, Lauren A. ^{[1
]}

Miller, James R. ^{[1
]}

Myers, Carl P. ^{[1
]}

Williams, Mary Elizabeth ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

INORGANIC CHEMISTRY | 2010年 / 49卷 / 11期

基金：

美国国家科学基金会;

关键词：

METAL COORDINATION; ELECTRON-TRANSFER; COMPLEXES; COPPER; ELECTROCHEMISTRY; SCAFFOLDS; NUMBER;

D O I：

10.1021/ic100252g

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two artificial dipeptides containing both a pendant monodentate (pyridine (py)) and tridentate (terpyridine (tpy) or phenyl terpyridine (phi-tpy)) ligand on an aminoethylglycine (aeg) backbone have been synthesized. These oligopeptides are fully characterized by one and two-dimensional NMR spectroscopy, mass spectrometry, and elemental analysis. The ligands were chosen because they coordinate Cu2+ to form [Cu(py)(tpy)](2+) complexes; when bound to the dipeptide scaffold, Cu2+ chelation cross-links the strands to form double-stranded duplex structures with an antiparallel arrangement. Using spectrophotometric titrations, we observe coordination of one Cu2+ metal per dipeptide strand. Mass spectrometry, NMR spectroscopy, vapor pressure osmometry, and HPLC confirm that the resulting structures are the dipeptide duplex cross-linked by two metal centers.

引用

页码：5126 / 5133

页数：8

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