Prenatal exposure to nicotine: Effects on prepulse inhibition and central nicotinic receptors

被引：36

作者：

Popke, EJ

Tizabi, Y

Rahman, MA

Nespor, SM

Grunberg, NE

机构：

[1] UNIFORMED SERV UNIV HLTH SCI, DEPT MED & CLIN PSYCHOL, BETHESDA, MD 20814 USA

[2] UNIFORMED SERV UNIV HLTH SCI, NEUROSCI PROGRAM, BETHESDA, MD 20814 USA

[3] HOWARD UNIV, COLL MED, DEPT PHARMACOL, WASHINGTON, DC 20059 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1997年 / 58卷 / 04期

关键词：

prenatal nicotine; prepulse inhibition; nicotinic receptors; sensory gating; sex differences;

D O I：

10.1016/S0091-3057(97)98985-1

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present experiment examined effects of prenatal nicotine exposure (6 mg/kg/day via osmotic minipump) throughout gestation on prepulse inhibition of the acoustic startle response (PPI) and on the density of nicotinic acetylcholine receptors (nAchRs) in the brains of 5-week-old Sprague-Dawley rats. A total of 117 male and 103 female offspring were used. Pre natal nicotine reduced subsequent percent PPI to a 98 dB stimulus in female but not in male offspring. There was an inverse correlation between the percent of PPI and nAchR density in the cortex of male rats and the striatum of female rats. (C) 1997 Elsevier Science Inc.

引用

页码：843 / 849

页数：7

共 35 条

[1] NICOTINE MODULATES EFFECTS OF STRESS ON ACOUSTIC STARTLE REFLEXES IN RATS - DEPENDENCE ON DOSE, STRESSOR AND INITIAL REACTIVITY [J].