Drug susceptibility of subtypes A, B, C, D, and E human immunodeficiency virus type 1 primary isolates

被引：92

作者：

Palmer, S

Alaeus, A

Albert, J

Cox, S

机构：

[1] Karolinska Inst, Swedish Inst Infect Dis Control, Dept Virol, Stockholm, Sweden

[2] Karolinska Inst, Ctr Microbiol & Tumor Biol, Stockholm, Sweden

[3] Karolinska Inst, Danderyd Hosp, Dept Infect Dis, S-18288 Danderyd, Sweden

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1998年 / 14卷 / 02期

关键词：

D O I：

10.1089/aid.1998.14.157

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We determined the susceptibility to antiviral drugs of clinical isolates of human immunodeficiency virus type 1 (HIV-1) subtypes A, B, C, D, and E, Isolates from treated and untreated patients were tested for sensitivity to zidovudine (ZDV), lamivudine (3TC), didanosine (ddI), nevirapine (NVP), foscarnet (PFA), and ritonavir (RNV), The susceptibility to these different drugs was broadly similar between the different subtypes of HIV-1, Isolates of subtype D showed a tendency toward slightly lower susceptibility to all the antiviral drugs, which could be related to the rapid growth characteristics of these isolates.

引用

页码：157 / 162

页数：6

共 38 条

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