Thiolate-bridged nickel-copper complexes: A binuclear model for the catalytic site of acetyl coenzyme A synthase?

被引：56

作者：

Krishnan, R ^{[1
]}

Voo, JK ^{[1
]}

Riordan, CG ^{[1
]}

Zahkarov, L ^{[1
]}

Rheingold, AL ^{[1
]}

机构：

[1] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 15期

关键词：

D O I：

10.1021/ja0346577

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of the nickel metalloligands [EtN2S2]Ni (EtN2S2, N,N′-diethyl-3,7-diazanonane-1,9-dithiolate) or K2[Ni(phmi)] (phmi, N,N′-1,2-phenylenebis(2-sulfanyl-2-methylpropionamide)) with [Cu(CH3CN)4]BF4 yields polynuclear complexes in which two copper(I) ions are bridged by the nickel metalloligands. Alternatively, reaction with the Cu(I) source, [(PhTttBu)Cu] (PhTttBu, phenyltris((tert-butylthio)methyl)borate), generates discrete binuclear NiCu complexes that may serve as models of the acetyl coenzyme A synthase active site. The binuclear species react reversibly with CO via rupture of the thiolate bridges. Copyright © 2003 American Chemical Society.

引用

页码：4422 / 4423

页数：2

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