Solubility, inhibited growth and dissolution kinetics of calcium oxalate crystals in solutions, containing alpha-ketoglutaric acid

被引：13

作者：

Atanassova, S

Neykov, K

Gutzow, I

机构：

[1] ALEXANDROVS UNIV HOSP,DEPT UROL,BU-1431 SOFIA,BULGARIA

[2] BULGARIAN ACAD SCI,INST PHYS CHEM,BU-1040 SOFIA,BULGARIA

来源：

JOURNAL OF CRYSTAL GROWTH | 1996年 / 160卷 / 1-2期

关键词：

D O I：

10.1016/0022-0248(95)00545-5

中图分类号：

O7 [晶体学];

学科分类号：

0702 [物理学]; 070205 [凝聚态物理]; 0703 [化学]; 080501 [材料物理与化学];

摘要：

The kinetics of dissolution of calcium oxalate (CaOX) calculi in physiological solutions containing alpha-ketoglutaric acids at different concentrations were studied, using the change in the Archimedean weight of samples immersed in the solution. It was found that alpha-ketoglutaric acid (a normal physiological constituent of urine) acts at increased concentrations as a dissolving agent with respect to CaOX calculi. Analysis of the experimental results enabled the determination of the increased solubility of calcium oxalate in the presence of alpha-ketoglutaric acid which can be defined as a new and promising agent for dissolving CaOX calculi in human urine. The inhibiting effect of alpha-ketoglutanic acid on CaOX precipitation in human urine is also discussed.

引用

页码：148 / 153

页数：6

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