Cirrhotic Cardiomyopathy

被引：286

作者：

Zardi, Enrico M. ^{[1
]}

Abbate, Antonio ^{[2
]}

Zardi, Domenico Maria ^{[3
]}

Dobrina, Aldo ^{[4
]}

Margiotta, Domenico ^{[1
]}

Van Tassel, Benjamin W. ^{[2
]}

Afeltra, Antonella ^{[1
]}

Sanyal, Arun J. ^{[5
]}

机构：

[1] Univ Campus Biomed, Dept Clin Med, I-20000128 Rome, Italy

[2] Virginia Commonwealth Univ, VCU Pauley Heart Ctr, Richmond, VA USA

[3] Univ Roma La Sapienza, Osped SantAndrea, Dept Cardiol, Sch Med 2, Rome, Italy

[4] Univ Trieste, Dept Physiol & Pathol, Trieste, Italy

[5] Virginia Commonwealth Univ, VCU Sch Med, Div Gastroenterol Hepatol & Nutr, Dept Internal Med, Richmond, VA USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2010年 / 56卷 / 07期

关键词：

cardiomyocyte; vascular dysfunction; cirrhosis; portal hypertension; INTRAHEPATIC PORTOSYSTEMIC SHUNT; RENAL SODIUM RETENTION; DUCT-LIGATED RATS; NITRIC-OXIDE; LIVER-TRANSPLANTATION; PORTAL-HYPERTENSION; CARDIAC MYOCYTES; HEART-FAILURE; SARCOPLASMIC-RETICULUM; VENTRICULAR MYOCYTES;

D O I：

10.1016/j.jacc.2009.12.075

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by an abnormal and blunted response to physiologic, pathologic, or pharmacologic stress but normal to increased cardiac output and contractility at rest. As many as 50% of cirrhotic patients undergoing liver transplantation show signs of cardiac dysfunction, and 7% to 21% of deaths after orthotopic liver transplantation result from overt heart failure. In this review, we critically evaluate the existing literature on the pathophysiology and clinical implications of cirrhotic cardiomyopathy. (J Am Coll Cardiol 2010;56:539-49) (C) 2010 by the American College of Cardiology Foundation

引用

页码：539 / 549

页数：11

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