Synthesis of ginsenoside Rg3, a minor constituent of Ginseng Radix

被引：32

作者：

Anufriev, VP ^{[1
]}

Malinovskaya, GV

Denisenko, VA

Uvarova, NI

Elyakov, GB

Kim, SI

Baek, NI

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Lab Organ Synth Nat Prod, Vladivostok 690022, Russia

[2] Korea Ginseng & Tobacco Inst, Div Biochem Pharmacol, Taejon, South Korea

来源：

CARBOHYDRATE RESEARCH | 1997年 / 304卷 / 02期

关键词：

alpha-acetobromosophorose; ginsenoside Rg(3); Ginseng Radix rubra;

D O I：

10.1016/S0008-6215(97)00217-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosylation of 12 beta-acetoxy-dammar-24-en-3 beta,20(S)-diol (4), with hepta-O-acetyl-alpha-sophorosyl bromide (5) under catalysis by Ag2CO3 or Ag2O afforded a chromatographically unseparated mixture of the alpha-and beta-linked octaacetates 6 and 7 in an approximately 2.5:1 ratio. After deprotection and chromatographic purification, the free alpha- (8) and beta-glycosides (9) were obtained. Sophoroside 9 was identical in all respects with ginsenoside Rg(3), the minor component of Ginseng Radix rubra. All compounds were fully characterized by H-1 and C-13 NMR spectroscopy, (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：179 / 182

页数：4

共 10 条

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ATOPKINA LN, 1989, KHIM PRIR SOEDIN, V6, P813

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