Identification of atranorin and related potential allergens in oakmoss absolute by high-performance liquid chromatography-tandem mass spectrometry using negative ion atmospheric pressure chemical ionization

被引：21

作者：

Hiserodt, RD ^{[1
]}

Swijter, DFH ^{[1
]}

Mussinan, CJ ^{[1
]}

机构：

[1] Int Flavors & Fragrances R&D, Union Beach, NJ 07735 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 888卷 / 1-2期

关键词：

oakmoss; atranorin; allergens;

D O I：

10.1016/S0021-9673(00)00495-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes the first high-performance liquid chromatographic-tandem mass spectrometric method for the identification of atranorin and related potential allergens in oakmoss absolute. Oakmoss absolute is ubiquitous in the fragrance industry and is a key component in many fine perfumes. However, oakmoss absolute causes an allergic response in some individuals. Research is focused toward establishing the identity of the compounds causing the allergic response so a quality controlled oakmoss with reduced allergenic potential can be prepared. Consequently a highly selective and specific analytical method is necessary to support this effort. This is not available with the existing HPLC methods using UV detection. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：103 / 111

页数：9

共 32 条

[1] Oakmoss Impact Volatiles Generated by a Basidiomycete of the Genus Polyporus [J].

Abraham, B. ;

Berger, R. G. ;

Schulz, H. .

FLAVOUR AND FRAGRANCE JOURNAL, 1994, 9 (05) :265-268

[2]

Arctander S., 1960, Perfume and Flavor Materials of Natural Origin

[3] SKIN SENSITIZATION STRUCTURE-ACTIVITY-RELATIONSHIPS FOR PHENYL BENZOATES [J].

BARRATT, MD ;

BASKETTER, DA ;

ROBERTS, DW .

TOXICOLOGY IN VITRO, 1994, 8 (04) :823-826

[4]

BARRATT MD, 1994, VITRO SKIN TOXICOLOG, P293

[5]

Basketter DA, 1999, J APPL TOXICOL, V19, P261, DOI 10.1002/(SICI)1099-1263(199907/08)19:4<261::AID-JAT572>3.3.CO

[6]

2-X

[7] The local lymph node assay: A viable alternative to currently accepted skin sensitization tests [J].

Basketter, DA ;

Gerberick, GF ;

Kimber, I ;

Loveless, SE .

FOOD AND CHEMICAL TOXICOLOGY, 1996, 34 (10) :985-997

[8]

Boelens Mans H., 1993, Perfumer and Flavorist, V18, P27

[9]

BROWN S, UNPUB

[10]

Chen S, 1999, RAPID COMMUN MASS SP, V13, P1869, DOI 10.1002/(SICI)1097-0231(19990930)13:18<1869::AID-RCM731>3.3.CO

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