Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current I-Ks by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide

被引：96

作者：

Selnick, HG

Liverton, NJ

Baldwin, JJ

Butcher, JW

Claremon, DA

Elliott, JM

Freidinger, RM

King, SA

Libby, BE

McIntyre, CJ

Pribush, DA

Remy, DC

Smith, GR

Tebben, AJ

Jurkiewicz, NK

Lynch, JJ

Salata, JJ

Sanguinetti, MC

Siegl, PKS

Slaughter, DE

Vyas, K

机构：

[1] MERCK RES LABS, DEPT PHARMACOL, West Point, PA 19486 USA

[2] MERCK RES LABS, DEPT DRUG METAB, West Point, PA 19486 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 40卷 / 24期

关键词：

D O I：

10.1021/jm970517u

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3865 / 3868

页数：4

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