Pyrimidine to guanine PDE inhibitors: determination of chemical course via structure elucidation

被引：8

作者：

Gala, D ^{[1
]}

DiBenedetto, DJ ^{[1
]}

Kugelman, M ^{[1
]}

Puar, MS ^{[1
]}

机构：

[1] Schering Plough Res Inst, Union, NJ 07083 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(03)00340-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Structure elucidation of several new pyrimidines containing a varying extent of hydrogen bonding allowed for determination of the course of chemical reactions towards the preparation of novel substituted pyrimidines. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2717 / 2720

页数：4

共 8 条

[1] Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity
Ahn, HS
Bercovici, A
Boykow, G
Bronnenkant, A
Chackalamannil, S
Chow, J
Cleven, R
Cook, J
Czarniecki, M
Domalski, C
Fawzi, A
Green, M
Gundes, A
Ho, G
Laudicina, M
Lindo, N
Ma, K
Manna, M
McKittrick, B
Mirzai, B
Nechuta, T
Neustadt, B
Puchalski, C
Pula, K
Silverman, L
Smith, E
Stamford, A
Tedesco, RP
Tsai, HG
Tulshian, D
Vaccaro, H
Watkins, RW
Weng, XY
Witkowski, JT
Xia, Y
Zhang, HT
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (14) : 2196 - 2210
[2] PREPARATION AND ABSOLUTE-CONFIGURATION OF TRANS-2-AMINOCYCLOPENTANOL ENANTIOMERS
BARR, AA
FRENCEL, I
ROBINSON, JB
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1977, 55 (24): : 4180 - 4183
[3] A novel synthesis of guanine PDE inhibitors via tricyclic imidazopyrimidines
Gala, D
DiBenedetto, DJ
Kugelman, M
Mitchell, MB
[J]. TETRAHEDRON LETTERS, 2003, 44 (13) : 2721 - 2723
[4] One-step synthesis of biphenylacetic acids via Pd/C-catalyzed arylation
Gala, D
Stamford, A
Jenkins, J
Kugelman, M
[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 1997, 1 (02) : 163 - 164
[5] Guanine hydrolysis under basic conditions to substituted imidazoles
Gala, D
Puar, MS
Czarniecki, M
Das, PR
Kugelman, M
Kaminski, JJ
[J]. TETRAHEDRON LETTERS, 2000, 41 (26) : 5025 - 5029
[6] A CONVENIENT METHOD FOR OBTAINING TRANS-2-AMINOCYCLOHEXANOL AND TRANS-2-AMINOCYCLOPENTANOL IN ENANTIOMERICALLY PURE FORM
OVERMAN, LE
SUGAI, S
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (21) : 4154 - 4155
[7] PFLEIDERER W, 1962, LIEBIGS ANN CHEM, V657, P149
[8] Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor
Vemulapalli, S
Watkins, RW
Chintala, M
Davis, H
Ahn, HS
Fawzi, A
Tulshian, D
Chiu, P
Chatterjee, M
Lin, CC
Sybertz, EJ
[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1996, 28 (06) : 862 - 869

← 1 →