Study of the British Pharmacopeia method on methimazole (thiamazole) content in carbimazole tablets

被引：32

作者：

Aletrari, M ^{[1
]}

Kanari, P ^{[1
]}

Partassides, D ^{[1
]}

Loizou, E ^{[1
]}

机构：

[1] Minist Hlth, State Gen Lab, CY-1451 Nicosia, Cyprus

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 16卷 / 05期

关键词：

carbimazole; methimazole (thiamazole); thin layer chromatography; high performance liquid chromatography;

D O I：

10.1016/S0731-7085(97)00119-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The analysis of carbimazole tablets in The British Pharmacopoeia, 1993, includes a quantitative thin layer chromatography (TLC) determination of methimazole. Repeated analysis of the same samples did not give similar results. The repeatability and reproducibility of the method was studied. It was proved that the residence time of the methimazole spot on the TLC plate is time dependent. (C) 1998 Elsevier Science B.V.

引用

页码：785 / 792

页数：8