Prognostic value of proton MR spectroscopy of cerebral hemisphere tumors in children

被引:42
作者
Girard, N
Wang, ZJ
Erbetta, A
Sutton, LN
Phillips, PC
Rorke, LB
Zimmerman, RA
机构
[1] Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA
[2] Hop Enfants La Timone, Dept Neuroradiol & Vasc Radiol, Marseille, France
[3] Ist Nazl Neurol C Besta, Dept Neuroradiol, Milan, Italy
[4] Childrens Hosp Philadelphia, Div Neurosurg, Philadelphia, PA 19104 USA
[5] Childrens Hosp Philadelphia, Neurooncol Program, Philadelphia, PA 19104 USA
[6] Childrens Hosp Philadelphia, Dept Neuropathol, Philadelphia, PA 19104 USA
关键词
proton magnetic resonance spectroscopy; brain tumor; pediatric; neuro-oncology; brain tumors; prognosis;
D O I
10.1007/s002340050551
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied 14 young people with newly diagnosed hemisphere tumors, aged from 3 to 20 years (average 10 years). All underwent surgery following MR imaging (MRI) and spectroscopy (MRS). The tumors studied were three glioblastomas, one each of ganglio-glioblastoma, primitive neuroectodermal tumor (PNET), rhabdoid teratoid tumor, pilocytic astrocytoma, ependymoma, anaplastic ependymoma, and gliomatosis cerebri, and four gang liogliomas. Four patients died; ten patients are alive (five with stable residual tumor, five with no evident tumor). Images and spectra were acquired on a 1.5-T imager. Proton MRS was performed before gadolinium injection in all but one case. Single-voxel techniques were utilized in all cases, using a spin-echo or STEAM sequence with a long echo time (135 or 270 ms). Peak areas of N-acetyl aspartate (NAA), choline (Cho), and creatine and phosphocreatine (Cr) were assessed. The NAA/Cho peak-area ratio was very low in the patients who died (mean +/- s. d. 0.20 +/- 0.14), and higher in the patients who are alive (0.74 +/- 0.47; P = 0.007 by two-tailed t-test). The Cr/Cho peak-area ratio also followed a similar trend for the two groups (mean +/- s. d. 0.17 +/- 0.07 and 0.49 +/- 0.30, respectively; P = 0.01 by two-tailed t-test).
引用
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页码:121 / 125
页数:5
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