Dual-Responsive Supramolecular Inclusion Complexes of Block Copolymer Poly(ethylene glycol)-block-Poly[(2-dimethylamino)ethyl methacrylate] with α-Cyclodextrin

被引：25

作者：

Sui, Kunyan ^{[1
,2
,3
]}

Shan, Xin ^{[1
,2
]}

Gao, Song ^{[1
,2
]}

Xia, Yanzhi ^{[1
,2
]}

Zheng, Qiang ^{[3
]}

Xie, Dan ^{[1
,2
]}

机构：

[1] Qingdao Univ, State Key Lab Cultivating Base New Fiber Mat & Mo, Qingdao 266071, Peoples R China

[2] Qingdao Univ, Dept Chem Engn, Qingdao 266071, Peoples R China

[3] Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2010年 / 48卷 / 10期

基金：

中国国家自然科学基金;

关键词：

alpha-cyclodextrin; block copolymers; hydrogels; inclusion chemistry; inclusion complexes; poly(ethylene glycol)-b-poly[(2-dimethylamino)ethyl methacrylate; self-assembly; stimuli-responsive hydrogel; stimuli-sensitive polymers; MOLECULAR-WEIGHT; TRIBLOCK COPOLYMERS; PHASE-TRANSITION; GLYCOL); HYDROGELS; POLYMERS; MICELLES; BEHAVIOR; OXIDE); WATER;

D O I：

10.1002/pola.23982

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new class of temperature and pH dual-responsive and injectable supramolecular hydrogel was developed, which was formed from block copolymer poly(ethylene glycol)-block-Poly[(2-dimethylamino)ethyl methacrylate] (PEG-b-PDMAEMA) and a-cyclodextrin (alpha-CD) inclusion complexes (ICs). The PEG-b-PDMAEMA diblock copolymers with different ratio of ethylene glycol (EG) to (2-dimethylaminolethyl methacrylate (DMAEMA) (102:46 and 102:96, respectively) were prepared by atom transfer radical polymerization (ATRP). H-1 NMR measurement indicated that the ratio of EG unit to alpha-CD in the resulted ICs was higher than 2:1. Thermal analysis showed that thermal stability of ICs was improved. The rheology studies showed that the hydrogels were temperature and pH sensitive. Moreover, the hydrogels were thixotropic and reversible. The self-assembly morphologies of the ICs in different pH and ionic strength environment were studied by transmission electron microscopy. The formed biocompatible micelles have potential applications as biomedical and stimulus-responsive material. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2143-2153, 2010

引用

页码：2143 / 2153

页数：11

共 51 条

[1]

Behr J.-P., 1994, LOCK AND KEY PRINCIP

[2] Synthesis and supramolecular organization of amphiphilic diblock copolymers combining poly(N,N-dimethylamino-2-ethyl methacrylate) and poly(ε-caprolactone) [J].

Bougard, Francois ;

Jeusette, Melanie ;

Mespouille, Laetitia ;

Dubois, Philippe ;

Lazzaroni, Roberto .

LANGMUIR, 2007, 23 (05) :2339-2345

[3] Synthesis of a new macromonomer from 2-(dimethylamino)ethyl methacrylate bearing 1-(isopropenylphenyl)-1,1-dimethylmethyl isocyanate group [J].

Boyer, C ;

Boutevin, G ;

Robin, JJ ;

Boutevin, B .

MACROMOLECULAR CHEMISTRY AND PHYSICS, 2004, 205 (05) :645-655

[4] Syntheses and characterizations of the multiple morphologies formed by the self-assembly of the sernicrystalline P4VP-b-PCL diblock copolymers [J].

Chan, Shih-Chi ;

Kuo, Shiao-Wei ;

Lu, Chu-Hua ;

Lee, Hsin-Fang ;

Chang, Feng-Chih .

POLYMER, 2007, 48 (17) :5059-5068

[5] Radiation synthesis of pH-sensitive hydrogels from β-cyclodextrin-grafted PEG and acrylic acid for drug delivery [J].

Chen, Jie ;

Rong, Liang ;

Lin, Han ;

Xiao, Ruijia ;

Wu, Huifeng .

MATERIALS CHEMISTRY AND PHYSICS, 2009, 116 (01) :148-152

[6] Temperature-responsive magnetite/PEO-PPO-PEO block copolymer nanoparticles for controlled drug targeting delivery [J].

Chen, Shu ;

Li, Ying ;

Guo, Chen ;

Wang, Jing ;

Ma, Junhe ;

Liang, Xiangfeng ;

Yang, Liang-Rong ;

Liu, Hui-Zhou .

LANGMUIR, 2007, 23 (25) :12669-12676

[7] Preparation and characterization of polypseudorotaxanes based on biodegradable poly(L-lactide)/poly(ethylene glycol) triblock copolymers [J].

Choi, HS ;

Ooya, T ;

Sasaki, S ;

Yui, N ;

Ohya, Y ;

Nakai, T ;

Ouchi, T .

MACROMOLECULES, 2003, 36 (25) :9313-9318

[8]

Easton C.J., 1999, MODIFIED CYCLODEXTRI

[9] Remarkably stable inclusion complexes with heptakis-[6-deoxy-6-(2-aminoethylsulfanyl)]-β-cyclodextrin [J].

Gomez-Biagi, Rodolfo F. ;

Jagt, Richard B. C. ;

Nitz, Mark .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (24) :4622-4626

[10] PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES OF POLY(PROPYLENE GLYCOL) WITH CYCLODEXTRINS [J].

HARADA, A ;

OKADA, M ;

LI, J ;

KAMACHI, M .

MACROMOLECULES, 1995, 28 (24) :8406-8411

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