Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b

被引：38

作者：

Loeser, Stefanie ^{[1
]}

Penninger, Josef M. ^{[1
]}

机构：

[1] Austrian Acad Sci, IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria

来源：

SEMINARS IN IMMUNOLOGY | 2007年 / 19卷 / 03期

关键词：

Cbl-b; T cell; tolerance; autommumity; TCR signaling; co-stimulation;

D O I：

10.1016/j.smim.2007.02.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The family of the Casitas B-lineage Lymphoma (Cbl) proteins, c-Cbl, Cbl-b, and Cbl-3, function as E3 ubiquitin ligases and molecular adaptors. In particular, Cbl-b acts as a gatekeeper in T cell activation that controls activation thresholds and the requirement for co-stimulation. Loss of Cbl-b expression renders animals susceptible to antigen-triggered autoinimunity suggesting that Cbl-b is a key autoinimunity gene. In addition, Cbl-b plays a critical role in T cell anergy and escape from regulatory T cells (Treg) suppression. Modulation of Cbl-b might provide us with a unique opportunity for future immune treatment of human disorders such as autoimmunity, immunodeficiency, or cancer. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：206 / 214

页数：9

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