Source of extracellular brain adenosine during hypoxia in fetal sheep

被引:32
作者
Koos, BJ [1 ]
Kruger, L
Murray, TF
机构
[1] Univ Calif Los Angeles, Dept Obstet & Gynecol, Nicholas S Assali Perinatal Res Lab, Sch Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Neurobiol, Inst Brain Res, Sch Med, Los Angeles, CA 90095 USA
[3] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA
关键词
brain; breathing; metabolism; respiration; fetus;
D O I
10.1016/S0006-8993(97)01207-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Microdialysis was performed to determine whether hypoxia increases fetal brain adenosine (ADO) concentration through dephosphorylation of extracellular 5'-adenosine monophosphate (5-AMP). Hypoxia(fetal PaO2, approximate to 14 Torr) increased fetal brain ADO levels similar to two-fold when the probes were perfused with synthetic cerebrospinal fluid (CSF) containing inhibitors of the nucleoside transporter but not with this solution plus a blocker of ecto-5'-nucleotidase (AOPCP). The hypoxia-induced rise in fetal brain ADO concentrations depends critically upon the hydrolysis of extracellular 5'-AMP. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:439 / 442
页数:4
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