Pulmonary fibrosis: Cellular and molecular events

被引:70
作者
Razzaque, MS
Taguchi, T
机构
[1] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA
[2] Nagasaki Univ, Grad Sch Med Sci, Dept Pathol, Nagasaki 852, Japan
关键词
collagen; fibrogenic factors; fibrosis; lung;
D O I
10.1046/j.1440-1827.2003.01446.x
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Connective tissue remodeling of the interstitium is an important feature of chronic lung diseases encompassing interstitial inflammatory changes and subsequent pulmonary fibrosis. The early inflammatory phase is usually associated with the release of several cytokines and chemokines by activated resident cells and infiltrating cells which, in turn, help further recruit inflammatory mononuclear cells. Cytokines and growth factors secreted by inflammatory cells and by interstitial cells (fibroblasts and myofibroblasts) play an important role in the fibrogenic phase of pulmonary fibrosis by inducing matrix synthesis. In addition, matrix-degrading enzymes and their inhibitors also contribute to extracellular matrix (ECM) remodeling in pulmonary fibrosis. This review addresses the pathophysiology of wound healing and different phases of pulmonary fibrosis.
引用
收藏
页码:133 / 145
页数:13
相关论文
共 140 条
  • [1] Abraham DJ, 1997, AM J PATHOL, V151, P831
  • [2] CELLS, MATRIX, GROWTH-FACTORS, AND THE SURGEON - THE BIOLOGY OF SCARLESS FETAL WOUND REPAIR
    ADZICK, NS
    LORENZ, HP
    [J]. ANNALS OF SURGERY, 1994, 220 (01) : 10 - 18
  • [3] Enhanced insulin-like growth factor finding protein-related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
    Allen, JT
    Knight, RA
    Bloor, CA
    Spiteri, MA
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 21 (06) : 693 - 700
  • [4] Pirfenidone in the treatment of primary sclerosing cholangitis
    Angulo, P
    MacCarty, RL
    Sylvestre, PB
    Jorgensen, RA
    Wiesner, RH
    LaRusso, NA
    Lindor, KD
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2002, 47 (01) : 157 - 161
  • [5] [Anonymous], 2002, AM J RESP CRIT CARE, V165, P277, DOI [DOI 10.1164/AJRCCM.165.2.ATS01, 10.1164/ajrccm.165.2.ats01]
  • [6] PLATELET-DERIVED GROWTH-FACTOR IN IDIOPATHIC PULMONARY FIBROSIS
    ANTONIADES, HN
    BRAVO, MA
    AVILA, RE
    GALANOPOULOS, T
    NEVILLEGOLDEN, J
    MAXWELL, M
    SELMAN, M
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (04) : 1055 - 1064
  • [7] Characterization of the enzyme involved in the processing of big endothelin-1 in human lung epithelial cells
    Aubert, JD
    Carnal, B
    Ricou, J
    Fioroni, P
    Juillerat-Jeanneret, L
    Pinet, F
    [J]. PULMONARY PHARMACOLOGY & THERAPEUTICS, 1998, 11 (2-3) : 209 - 213
  • [8] Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor
    Bickel, M
    Baringhaus, KH
    Gerl, M
    Günzler, V
    Kanta, J
    Schmidts, L
    Stapf, M
    Tschank, G
    Weidmann, K
    Werner, U
    [J]. HEPATOLOGY, 1998, 28 (02) : 404 - 411
  • [9] THE LONG-TERM PROGNOSIS OF THE PRIMARY GLOMERULONEPHRITIDES - A MORPHOLOGICAL AND CLINICAL ANALYSIS OF 1747 CASES
    BOHLE, A
    WEHRMANN, M
    BOGENSCHUTZ, O
    BATZ, C
    VOGL, W
    SCHMITT, H
    MULLER, CA
    MULLER, GA
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 1992, 188 (07) : 908 - 924
  • [10] CONNECTIVE-TISSUE GROWTH-FACTOR - A CYSTEINE-RICH MITOGEN SECRETED BY HUMAN VASCULAR ENDOTHELIAL-CELLS IS RELATED TO THE SRC-INDUCED IMMEDIATE EARLY GENE-PRODUCT CEF-10
    BRADHAM, DM
    IGARASHI, A
    POTTER, RL
    GROTENDORST, GR
    [J]. JOURNAL OF CELL BIOLOGY, 1991, 114 (06) : 1285 - 1294