Immunocytochemical study of catecholaminergic neurons in the senescence-accelerated mouse (SAM-P8) brain

被引:18
作者
Karasawa, N [1 ]
Nagatsu, I
Sakai, K
Nagatsu, T
Watanabe, K
Onozuka, M
机构
[1] Fujita Hlth Univ, Sch Med, Dept Anat, Toyoake, Aichi 47011, Japan
[2] Fujita Hlth Univ, Sch Med, Inst Comprehens Med Sci, Toyoake, Aichi 47011, Japan
[3] Gifu Univ, Sch Med, Dept Physiol, Gifu 500, Japan
[4] Gifu Univ, Sch Med, Dept Anat, Gifu 500, Japan
关键词
catecholamine; senescence-accelerated mouse (SAM-P8); immunocytochemistry; aging;
D O I
10.1007/BF01294727
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The catecholaminergic neurons of senescence-accelerated mice (SAM-P8) were analyzed by immunohistochemical microphotometry in terms of immunoreactivities to aromatic L-amino acid decarboxylase (AADC), dopamine (DA), or noradrenaline (NA). Accelerated senescence-resistant mice (SAM-RI) were used as control mice. The immunoreactivities to AADC, DA, and NA of the catecholaminergic neurons of the SAM-Pa mice were weaker than those of the SAM-RI mice in all the brain regions. Immunoelectron microscopy revealed progressive degeneration of dopaminergic neurons and their terminal fibers in the substantia nigra as well as in noradrenergic neurons and their proximal dendrites in the locus coeruleus of the SAM-P8 mice. In contrast, there was no difference between the SAM-P8 and SAM-RI mice in the distribution of AADC-only positive neurons (designated as D neurons in the rat brain by Jaeger et al.) nor in their immunoreactivities. These results may indicate that DA neurons in the substantia nigra and NA neurons in the locus coeruleus degenarate more rapidly during aging in SAM-P8 mice than in control SAM-RI mice and that D neurons may function as a part of a compensatory system for the decreases in catecholaminergic neurons during aging.
引用
收藏
页码:1267 / 1275
页数:9
相关论文
共 30 条
[1]  
AILARD P, 1989, NEUROBIOL AGING, V10, P661
[2]  
ARAI H, 1984, J NEUROCHEM, V43, P388
[3]   BRAIN CATECHOLAMINE CONTENT AND TURNOVER IN AGING RATS [J].
CARFAGNA, N ;
TRUNZO, F ;
MORETTI, A .
EXPERIMENTAL GERONTOLOGY, 1985, 20 (05) :265-269
[4]   AGE-RELATED-CHANGES IN RAT-BRAIN MONOAMINES RELEASE - PECULIARITY OF DOPAMINE RELEASE [J].
CERRITO, F ;
ALOISI, G ;
ARMINIO, P .
JOURNAL OF NEUROSCIENCE RESEARCH, 1993, 34 (03) :364-370
[5]   GRADING SCORE SYSTEM - A METHOD FOR EVALUATION OF THE DEGREE OF SENESCENCE IN SENESCENCE ACCELERATED MOUSE (SAM) [J].
HOSOKAWA, M ;
KASAI, R ;
HIGUCHI, K ;
TAKESHITA, S ;
SHIMIZU, K ;
HAMAMOTO, H ;
HONMA, A ;
IRINO, M ;
TODA, K ;
MATSUMURA, A ;
MATSUSHITA, M ;
TAKEDA, T .
MECHANISMS OF AGEING AND DEVELOPMENT, 1984, 26 (01) :91-102
[6]   MORPHOLOGICAL AND BIOCHEMICAL-CHANGES IN THE CHOLINERGIC AND MONOAMINERGIC SYSTEMS IN ALZHEIMER-TYPE DEMENTIA [J].
ICHIMIYA, Y ;
ARAI, H ;
KOSAKA, K ;
IIZUKA, R .
ACTA NEUROPATHOLOGICA, 1986, 70 (02) :112-116
[7]  
IRWIN I, 1994, NEURODEGENERATION, V3, P251
[8]   SOME NEURONS OF THE RAT CENTRAL NERVOUS-SYSTEM CONTAIN AROMATIC-L-AMINO-ACID DECARBOXYLASE BUT NOT MONOAMINES [J].
JAEGER, CB ;
TEITELMAN, G ;
JOH, TH ;
ALBERT, VR ;
PARK, DH ;
REIS, DJ .
SCIENCE, 1983, 219 (4589) :1233-1235
[9]   Murine models of brain aging and age-related neurodegenerative diseases [J].
Jucker, M ;
Ingram, DK .
BEHAVIOURAL BRAIN RESEARCH, 1997, 85 (01) :1-25
[10]   Chemical features of monoaminergic and non-monoaminergic neurons in the brain of laboratory shrew (Suncus murinus) are changed by systemic administration of monoamine precursors [J].
Karasawa, N ;
Arai, R ;
Isomura, G ;
Nagatsu, T ;
Nagatsu, I .
NEUROSCIENCE RESEARCH, 1995, 24 (01) :67-74