Persistent infectious diseases say - IDO. Role of indoleamine-2,3-dioxygenase in disease pathogenesis and implications for therapy

被引：35

作者：

Barth, Heidi ^{[1
,2
,3
]}

Raghuraman, Sukanya ^{[4
]}

机构：

[1] INSERM, U748, F-67000 Strasbourg, France

[2] Hop Univ Strasbourg, Virol Lab, Strasbourg, France

[3] Univ Strasbourg, Strasbourg, France

[4] Univ New S Wales, Sch Med Sci, UNSW Med, Inflammat & Infect Res Ctr, Sydney, NSW, Australia

来源：

CRITICAL REVIEWS IN MICROBIOLOGY | 2014年 / 40卷 / 04期

基金：

英国医学研究理事会;

关键词：

Anti-microbial defense; immune regulation; infectious tolerance; immunotherapy; persistent pathogens; REGULATORY T-CELLS; HEPATITIS-C VIRUS; 2,3-DIOXYGENASE-EXPRESSING DENDRITIC CELLS; TUMOR-NECROSIS-FACTOR; INDOLEAMINE 2,3-DIOXYGENASE; TRYPTOPHAN CATABOLISM; INTERFERON-GAMMA; KYNURENINE PATHWAY; POSTTRANSLATIONAL REGULATION; EXPERIMENTAL ASTHMA;

D O I：

10.3109/1040841X.2012.742037

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Indoleamine-2,3-dioxygenase (IDO) is an enzyme that catabolises tryptophan - an essential amino acid critical for T cell proliferation. Initially recognized as a first line of host defense against infectious pathogens, IDO has been subsequently identified as an important immune-regulator inhibiting T-cell responses and promoting immune tolerance. Research over the past few years has demonstrated a crucial role for IDO in the pathogenesis of persistent infections that place an enormous burden on public health. In this review, we summarize current knowledge about IDO's role in causing pathogen persistence and progression to clinical disease. We conclude with a perspective on the potential benefits and risks of therapeutic IDO manipulation.

引用

页码：360 / 368

页数：9

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