The total synthesis of (-)-tetrahydrolipstatin

被引：35

作者：

Bodkin, JA ^{[1
]}

Humphries, EJ ^{[1
]}

McLeod, MD ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Camperdown, NSW 2006, Australia

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 14期

关键词：

(-)-tetrahydrolipstatin; bromolactonisation; beta-lactone; radical dehalogenation;

D O I：

10.1016/S0040-4039(03)00443-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Careful control during the bromolactonisation of beta,gamma-unsaturated acid 3 was required to afford regioselectively the trans-beta-lactone 4 as the major diastereomer. Radical debromination of 4 followed by a three-step sequence of reactions afforded the lipase inhibitor (-)-tetrahydrolipstatin. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2869 / 2872

页数：4

共 39 条

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