Organogenesis of lymphoid tissues

被引：560

作者：

Mebius, RE ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 04期

关键词：

D O I：

10.1038/nri1054

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of lymphoid organs depends on the correct expression of several molecules within a defined timeframe during ontogeny. Although this is an extremely complex process, with each secondary lymphoid tissue requiring subtly different signals, a common framework for lymphoid development is beginning to emerge. Drawing on studies of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines, which emphasizes the role of interactions between CD3(-)CD4(+)CD45(+) 'inducer' cells and VCAM1(+)ICAM1(+) stromal, 'organizer' cells is presented.

引用

页码：292 / 303

页数：12

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