Antibacterial resistance worldwide: causes, challenges and responses

被引：2904

作者：

Levy, SB ^{[1
]}

Marshall, B

机构：

[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Ctr Adaptat Genet & Drug Resistance, Boston, MA 02111 USA

[2] Tufts Univ, Sch Med, Dept Med, Ctr Adaptat Genet & Drug Resistance, Boston, MA 02111 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 12期

关键词：

D O I：

10.1038/nm1145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance-the legacy of past decades of antimicrobial use and misuse. Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs.

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页码：S122 / S129

页数：8

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