Hypoxic-ischemic encephalopathy in areas of primary myelination: A neuroimaging and PET study

被引:32
作者
Azzarelli, B
Caldemeyer, KS
Phillips, JP
DeMyer, WE
机构
[1] INDIANA UNIV,SCH MED,DEPT PATHOL,DIV NEUROPATHOL,INDIANAPOLIS,IN 46202
[2] INDIANA UNIV,SCH MED,DEPT RADIOL,DIV NEURORADIOL,INDIANAPOLIS,IN 46202
[3] INDIANA UNIV,SCH MED,DEPT NEUROL,INDIANAPOLIS,IN 46202
关键词
D O I
10.1016/0887-8994(96)00010-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The stage of regional structural and biochemical development of the central nervous system appears as a critical factor determining the distribution of hypoxic-ischemia lesions during the perinatal period. We describe the brain lesions in 12 patients who suffered hypoxia-ischemia during the perinatal period. The gestational age ranged from 35 to 42 weeks and the age at death from 2 to 16 weeks. There is one patient alive at age 18 years and a second patient at age 1 year. The cerebral cortical damage is mainly restricted to areas of primary myelination and adjacent subcortical white matter, In addition, there is thalamic, basal ganglia, brainstem, and spinal cord damage, It is postulated that selective damage occurs in those areas which at the moment of the hypoxic-ischemic insult had achieved higher rates of oxygen-glucose utilization. This hypothesis is supported by studies utilizing positron emission tomography which indicates that glucose utilization in the normal human neonatal brain follows a phylogenetic order, Regions that achieved higher levels of glucose consumption are those that suffered the brunt of the damage in our term neonates.
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页码:108 / 116
页数:9
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