Pharmacological activities of stromata of Cordyceps scarabaecola

被引:12
作者
Yu, KW
Kim, KM
Suh, HJ
机构
[1] Korea Univ, Coll Hlth Sci, Dept Food & Nutr, Sungbuk Gu, Seoul 136703, South Korea
[2] Chongju Natl Coll Sci & Technol, Dept Kimchi & Food Sci, Jeungpyung 367701, South Korea
[3] Neurotide LTD, Chunchon 200161, South Korea
关键词
Cordyceps scarabaecola; stromata; anticoagulant; intestinal immune system modulation; anticomplementary; inhibition of radical generation;
D O I
10.1002/ptr.1119
中图分类号
R914 [药物化学];
学科分类号
100701 [药物化学];
摘要
The chemical components of freeze-dried stromata from Cordyceps scarabaecola were examined. The stromata consisted of crude carbohydrates (55.1%) and crude proteins (14.2%). The stromata were also composed of a low content of crude ash (6.6%) and fat (1.5%). The composition of the carbohydrate in the stromata included a large quantity of glucose (46.6%), mannose (35.4%) and galactose (18.0%). The acidic amino acids such as glutamic acid (32.1 mg/g) and aspartic acid (24.7 mg/g) were present in a large quantity. The extracts of stromata did not reveal any inhibitory activity for AChE in vitro. It was observed that a hot-water extract (HW) of the stromata contributed significantly to the anticoagulant activity (60 s coagulating time) and anticomplementary activity (62% of ITCH50 value). The MeOH-soluble fraction (M) from the freeze-dried stromata inhibited TPA-induced O-2(-) generation as effectively as the positive control, genistine 27%. The hot-water extract (HW) showed the most potent intestinal immune system modulation activity and the MeOH-soluble fraction (M) had intermediate activity. Copyright (C) 2003 John Wiley Sons, Ltd.
引用
收藏
页码:244 / 249
页数:6
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