Complications in investigations of the swelling of hydrogel matrices due to the presence of trapped gas

被引：22

作者：

Fyfe, CA ^{[1
]}

Blazek, AI ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

JOURNAL OF CONTROLLED RELEASE | 1998年 / 52卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

NMR imaging; controlled release; hydrophilic matrix tablet; swelling; hydroxypropylmethylcellulose;

D O I：

10.1016/S0168-3659(97)00217-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In recent studies, NMR imaging has been used to investigate the swelling of hydroxypropylmethylcellulose (HPMC) tablets and to determine polymer concentration distributions in the swollen matrix. The total amount of polymer in the system was computed from these distributions and was up to 35% greater than the known weight of HPMC in the tablet. This deviation was traced to the presence of air bubbles in the swollen matrix which occupied a significant volume previously assumed to be occupied by polymer and water. When the air in the tablet was removed by vacuum, the swollen gel contained no evidence of air bubbles and the calculated total polymer weights from the HPMC distributions were equal to the amount of HPMC in the tablet. (C) 1998 Elsevier Science B.V.

引用

页码：221 / 225

页数：5

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