Biology and polymer physics at the single-molecule level

被引:27
作者
Chu, S [1 ]
机构
[1] Stanford Univ, Dept Phys, Stanford, CA 94305 USA
来源
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2003年 / 361卷 / 1805期
关键词
single-molecule biology; polymer dynamics; biological physics; RNA folding; ribosome kinetics;
D O I
10.1098/rsta.2002.1157
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The ability to look at individual molecules has given us new insights into molecular processes. Examples of our recent work are given to illustrate how behaviour that may otherwise be hidden from view can be clearly seen in single-molecule experiments.
引用
收藏
页码:689 / 698
页数:10
相关论文
共 37 条
[1]   OBSERVATION OF A SINGLE-BEAM GRADIENT FORCE OPTICAL TRAP FOR DIELECTRIC PARTICLES [J].
ASHKIN, A ;
DZIEDZIC, JM ;
BJORKHOLM, JE ;
CHU, S .
OPTICS LETTERS, 1986, 11 (05) :288-290
[2]   The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution [J].
Ban, N ;
Nissen, P ;
Hansen, J ;
Moore, PB ;
Steitz, TA .
SCIENCE, 2000, 289 (5481) :905-920
[3]   SCANNING TUNNELING MICROSCOPY - FROM BIRTH TO ADOLESCENCE [J].
BINNIG, G ;
ROHRER, H .
REVIEWS OF MODERN PHYSICS, 1987, 59 (03) :615-625
[4]   BEAD MOVEMENT BY SINGLE KINESIN MOLECULES STUDIED WITH OPTICAL TWEEZERS [J].
BLOCK, SM ;
GOLDSTEIN, LSB ;
SCHNAPP, BJ .
NATURE, 1990, 348 (6299) :348-352
[5]   Structural insights into the molecular mechanism of calcium-dependent vesicle-membrane fusion [J].
Brunger, AT .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2001, 11 (02) :163-173
[6]  
Butcher SE, 1999, NAT STRUCT BIOL, V6, P212
[7]   Solution structure of loop a from the hairpin ribozyme from tobacco ringspot virus satellite [J].
Cai, ZP ;
Tinoco, I .
BIOCHEMISTRY, 1996, 35 (19) :6026-6036
[8]   LASER MANIPULATION OF ATOMS AND PARTICLES [J].
CHU, S .
SCIENCE, 1991, 253 (5022) :861-866
[9]  
CHU S, 1990, INT QUANT EL C TECH, P202
[10]   SINGLE MYOSIN MOLECULE MECHANICS - PICONEWTON FORCES AND NANOMETER STEPS [J].
FINER, JT ;
SIMMONS, RM ;
SPUDICH, JA .
NATURE, 1994, 368 (6467) :113-119