Kinetics of weak distance-dependent hole transfer in DNA by adenine-hopping mechanism

被引：67

作者：

Kawai, K ^{[1
]}

Takada, T ^{[1
]}

Tojo, S ^{[1
]}

Majima, T ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, SANKEN, Ibaraki, Osaka 5670047, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 23期

关键词：

D O I：

10.1021/ja034953j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The kinetics of hole transfer in DNA by adenine-hopping mechanism was investigated by the combined pulse radiolysis-laser flash photolysis method. The hole transfer from Ptz•+* to oxG across the (A)n-bridge preceded by the A-hopping mechanism and the weak distance-dependent hole transfer with the rates faster than 108 s-1 over the distance range of 7-22 Å was demonstrated. In contrast, hole transfer from oxG•+ to Ptz followed the single-step super exchange mechanism. Thus, two different processes for the hole transfer across the identical (A)n-bridge in DNA have been demonstrated. The results clearly show that the mechanism of hole transfer in DNA strongly depends on the redox nature of the oxidant, whether it produces only G•+ or both A•+ and G•+. Copyright © 2003 American Chemical Society.

引用

页码：6842 / 6843

页数：2

共 28 条

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