Porcine KLF gene family: Structure, mapping, and phylogenetic analysis

被引：24

作者：

Chen, Zhilong ^{[1
]}

Lei, Ting ^{[1
]}

Chen, Xiaodong ^{[1
]}

Zhang, Jian ^{[1
]}

Yu, An ^{[1
]}

Long, Qinqiang ^{[1
]}

Long, Huan ^{[1
]}

Jin, Dan ^{[1
]}

Gan, Li ^{[2
]}

Yang, Zaiqing ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Life Sci & Technol, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China

[2] Huazhong Agr Univ, Coll Plant Sci & Technol, Wuhan 430070, Peoples R China

来源：

GENOMICS | 2010年 / 95卷 / 02期

基金：

中国国家自然科学基金;

关键词：

KLFs; Pig; Clone; Structure; Chromosome mapping; Phylogenetic analysis; KRUPPEL-LIKE FACTOR; ZINC-FINGER PROTEIN; TRANSCRIPTION FACTOR; NUCLEAR-LOCALIZATION; BINDING PROTEIN; REPRESSION; CELL; REGULATOR; KRUPPEL-LIKE-FACTOR-4; DIFFERENTIATION;

D O I：

10.1016/j.ygeno.2009.11.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Kruppel-like factors (KLFs) belong to the family of zinc finger-containing transcription factors that regulates a diverse array of cellular processes, including cell proliferation, differentiation, and apoptosis. Here we reported the structure, mapping and phylogenetic analysis of KLF gene family in pigs. Comparative analyses revealed strong conservation between pig and human KLFs at the genomic and protein structure levels. Porcine KLF 1-17 were dispersedly located on chromosomes 1, 2, 3, 4, 6, 7, 8, 10, 11, 15, 18 and X, respectively. Based on the phylogenetic analysis, we proposed that KLFs have undergone extensive expansion over the course of evolution. Finally, we identified a characteristic motif in KLF zinc finger domains that can be used to accurately predict potential KLF proteins. The current work represents the first comprehensive study of KLF genes in pigs and provides a foundation for future studies concerning structural, functional, and evolutionary analyses of KLF gene family. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：111 / 119

页数：9

共 44 条

[1] The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-γ expression and adipogenesis [J].