Prolonged hemodynamic stability during arteriovenous carbon dioxide removal for severe respiratory failure

被引:27
作者
Brunston, RL
Tao, WK
Bidani, A
Alpard, SK
Traber, DL
Zwischenberger, JB
机构
[1] Univ Texas, Div Cardiothorac Surg, Med Branch, Galveston, TX 77550 USA
[2] Univ Texas, Dept Surg, Med Branch, Galveston, TX 77550 USA
[3] Univ Texas, Dept Med, Med Branch, Galveston, TX 77550 USA
[4] Univ Texas, Dept Anesthesiol, Med Branch, Galveston, TX 77550 USA
[5] Shriners Burns Inst, Galveston, TX USA
关键词
D O I
10.1016/S0022-5223(97)70026-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The effects of prolonged arteriovenous carbon dioxide removal on hemodynamics during severe respiratory failure were evaluated in adult sheep with severe smoke inhalation injury. Methods: Adult female sheep (n = 6, 33.8 +/- 5.2 kg) were subjected to intratracheal cotton severe smoke insufflation to a mean carboxyhemoglobin level of 83% +/- 3%. Twenty-four hours after injury, a low-resistance 2.5 m(2) membrane oxygenator was placed in a carotid-to-jugular pumpless arteriovenous shunt at unrestricted flow to allow complete carbon dioxide removal and reductions in ventilator support. Animals remained conscious, and heart rate, cardiac output, mean arterial pressure, and pulmonary arterial pressure were measured at baseline, after injury, and daily during support with the arteriovenous carbon dioxide removal circuit for 7 days. Results: All animals survived the study period. Carbon dioxide removal ranged from 99.7 +/- 13.7 to 152.2 +/- 16.2 ml/min, and five (83%) of the six animals were successfully weaned from the ventilator before day 7. During full support with the arteriovenous carbon dioxide removal circuit, shunt flow ranged from 1.24 +/- 0.06 to 1.43 +/- 0.08 L/min and accounted for 20.1% +/- 1.4% to 25.9% +/- 2.4% of cardiac output. No statistically significant changes in heart rate, cardiac output, mean arterial pressure, or pulmonary artery pressure were demonstrated over the study course despite the extracorporeal shunt flow. Conclusions: Arteriovenous carbon dioxide removal as a simplified means of extracorporeal gas exchange support is relatively safe without adverse hemodynamic effects or complications.
引用
收藏
页码:1107 / 1114
页数:8
相关论文
共 33 条
[1]   PROLONGED PUMPLESS ARTERIOVENOUS PERFUSION FOR CARBON-DIOXIDE EXTRACTION [J].
AWAD, JA ;
DESLAURIERS, J ;
MAJOR, D ;
LIU, GJ ;
MARTIN, L .
ANNALS OF THORACIC SURGERY, 1991, 51 (04) :534-540
[2]  
BARTHELEMY R, 1982, T AM SOC ART INT ORG, V28, P354
[3]  
BRUNSTEIN RL, IN PRESS ANN THORAC
[4]  
BRUNSTON RL, 1996, ASAIO J, V42, P845
[5]   Correction of blood pH attenuates changes in hemodynamics and organ blood flow during permissive hypercapnia [J].
Cardenas, VJ ;
Zwischenberger, JB ;
Tao, WK ;
Nguyen, PDJ ;
Schroeder, T ;
Traber, LD ;
Traber, DL ;
Bidani, A .
CRITICAL CARE MEDICINE, 1996, 24 (05) :827-834
[6]  
CHAPMAN J, 1990, J THORAC CARDIOV SUR, V99, P741
[7]   CORRELATION BETWEEN CARDIOPULMONARY CHANGES AND SEVERITY OF ACUTE LUNG INJURY IN DOGS [J].
CHIANG, CH ;
SHEN, CY ;
HSU, K .
CRITICAL CARE MEDICINE, 1990, 18 (04) :419-422
[8]  
DEMLING RH, 1995, ANNU REV MED, V46, P193
[9]   BRONCHIAL VASCULAR OCCLUSION DOES NOT ATTENUATE OR ACCENTUATE OLEIC-ACID LUNG INJURY IN ANESTHETIZED SHEEP [J].
DODEK, PM ;
VALENZUELA, A ;
MINSHALL, DK ;
BAILE, EM ;
PARE, PD .
JOURNAL OF APPLIED PHYSIOLOGY, 1993, 75 (06) :2671-2676
[10]  
FLAIM SF, 1979, AM J PHYSIOL, V236, pH697