Structure of a drug-induced DNA T-bulge: Implications for DNA frameshift mutations

被引：14

作者：

Colgrave, ML ^{[1
]}

Williams, HEL ^{[1
]}

Searle, MS ^{[1
]}

机构：

[1] Sch Chem, Nottingham NG7 2RD, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 24期

关键词：

D O I：

10.1002/anie.200290039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A bulged conformation in which the T3 base is flipped-out of the helical stack of the novel DNA hairpin H2 allowing complementary pairing downstream of the intercalation site (see picture) is stabilized by binding of the drug nogalamycin. This finding was readily confirmed by detailed analysis of the chemical shift and NOE data.

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页码：4754 / 4756

页数：3

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