[1] Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
[2] Univ Bristol, Dept Physiol & Pharmacol, Bristol BS8 1TD, Avon, England
[3] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England
[4] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England