Drosophila neuromuscular synapse assembly and function require the TGF-β type I receptor saxophone and the transcription factor mad

被引:111
作者
Rawson, JM
Lee, M
Kennedy, EL
Selleck, SB
机构
[1] Univ Arizona, Dept Mol & Cellular Biol, ARL Div Neurobiol, Tucson, AZ 85724 USA
[2] Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA
来源
JOURNAL OF NEUROBIOLOGY | 2003年 / 55卷 / 02期
关键词
neurogenetics; neuromuscular junction; TGF-beta; synaptic development; physiology;
D O I
10.1002/neu.10189
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Transforming growth factor-betas (TGF-beta) comprise a superfamily of secreted proteins with diverse functions in patterning and cell division control. TGF-beta signaling has been implicated in synapse assembly and plasticity in both vertebrate and invertebrate systems. Recently, wishful thinking, a Drosophila gene that encodes a protein related to BMP type II receptors, has been shown to be required for the normal function and development of the neuromuscular junction (NMJ). These findings suggest that a TGF-beta-related ligand activates a signaling cascade involving type I and II receptors and the Smad family of transcription factors to orchestrate the assembly of the NMJ. Here we demonstrate that the TGF-beta type I receptor Saxophone and the downstream transcription factor Mothers against dpp (Mad) are essential for the normal structural and functional development of the Drosophila NMJ, a synapse that displays activity-dependent plasticity. (C) 2003 Wiley Periodicals, Inc.
引用
收藏
页码:134 / 150
页数:17
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